Physicochemical properties and in vivo evaluation of Pt/TiO2–SiO2 nanopowders
| Autor: | Daniel Cerna Álvarez, Ana Silvestre-Albero, Enrique Rodríguez-Castellón, Paola Ramírez, Francisco Rodríguez-Reinoso, Esteban Gómez, Tessy López-Goerne |
|---|---|
| Přispěvatelé: | Universidad de Alicante. Departamento de Química Inorgánica, Materiales Avanzados |
| Rok vydání: | 2018 |
| Předmět: |
Materials science
Biomedical Engineering Pt/TiO2–SiO2 nanopowders Medicine (miscellaneous) chemistry.chemical_element Catalytic nanomedicine Bioengineering Nanotechnology 02 engineering and technology Development 010402 general chemistry Platinum nanoparticles 01 natural sciences Nanomaterials Catalysis In vivo Ultra-small platinum nanoparticles Animal model General Materials Science Sol–gel technique Química Inorgánica 021001 nanoscience & nanotechnology 0104 chemical sciences Diabetic foot chemistry Wounds healing Nanomedicine Mixed oxide 0210 nano-technology Mesoporous material Platinum |
| Zdroj: | Nanomedicine. 13:2171-2185 |
| ISSN: | 1748-6963 1743-5889 |
| DOI: | 10.2217/nnm-2018-0078 |
| Popis: | Aim: Sol–gel is a suitable and advantageous method to synthesize mixed oxide nanomaterials with unique physicochemical and biological properties. Materials & methods: In this work, TiO2–SiO2 nanopowders cogeled with platinum acetylacetonate were developed and studied in the perspective of nanomedicine. The physicochemical properties of the Pt/TiO2–SiO2 nanopowders, named NanoRa2-Pt, were evaluated in detail by means of complementary spectroscopic and microscopic tools. The nanopowder's biocatalytic efficiency in wound healing was evaluated in a Type I diabetes animal model. Results: These are TiO2–SiO2 submicron mesoporous particles with variable size and shape containing ultra-small platinum nanoparticles with catalytic properties. Conclusion: The use of NanoRa2-Pt catalyzes the natural healing processes with a faster remodeling stage. These sols, which we call nanobiocatalysts, belong to an emerging and very promising research field known as catalytic nanomedicine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|