Lead accumulation pattern and molecular biomarkers of oxidative stress in seabream (Sparus aurata) under short-term metal treatment
| Autor: | Fatma Yaktiti, Khira Maaroufi, Ghada Souid, Nouha Souayed |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Time Factors Health Toxicology and Mutagenesis Toxicology medicine.disease_cause Antioxidants Lipid peroxidation Superoxide dismutase chemistry.chemical_compound Internal medicine medicine Animals Tissue Distribution Pharmacology Chemical Health and Safety biology Public Health Environmental and Occupational Health Neurotoxicity General Medicine Glutathione medicine.disease Acute toxicity Sea Bream Oxidative Stress Endocrinology chemistry Biochemistry Lead Catalase Bioaccumulation biology.protein Lipid Peroxidation Oxidative stress Biomarkers Water Pollutants Chemical |
| Zdroj: | Drug and chemical toxicology. 38(1) |
| ISSN: | 1525-6014 |
| Popis: | The present work aimed to look at the distribution and accumulation pattern of Lead (Pb) within the fish body after 2 h, 4 h and 24 h of waterborne exposure to the metal at 0.75 mg/L. Tests of lead acute toxicity and bioaccumulation were performed in the common fish species Sparus aurata. In our study, we assessed the oxidative stress damages extent after 2 h, 4 h and 24 h of exposure to lead using the enzymatic stress biomarkers: Superoxide Dismutase (SOD), Catalase (CAT) and Gluthathione (GSH). The lipid peroxidation (LPO) was also investigated by dosing Malondyhaldehyde (MDA) quantities in the liver tissue. The acute neurotoxicity of Pb was evaluated in the dorsal white muscle using the Acethylcholenesterase (AchE) activity. The liver tissue accumulates preferentially the metal, followed by the intestines, the gills and finally the dorsal muscle. The antioxidant response failed to prevent the lipid peroxidation and the neurotoxic effect of lead after 24 h of exposure. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|