Conformation-regulated mechanosensory control via titin domains in cardiac muscle
| Autor: | Wolfgang A. Linke, Tobias Voelkel |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Sarcomeres
Cardiac muscle mechanics Protein Conformation Physiology Clinical Biochemistry Protein domain Muscle Proteins Obscurin Cardiomyocyte macromolecular substances Signal transduction Biology Mechanotransduction Cellular Sarcomere Physiology (medical) medicine Animals Protein Isoforms Connectin Mechanotransduction Cytoskeleton Passive tension Invited Review Passive stiffness Myocardium Cardiac muscle Heart Elasticity Protein Structure Tertiary Cell biology Cardiac hypertrophy medicine.anatomical_structure cardiovascular system biology.protein Titin Stress Mechanical Protein Kinases |
| Zdroj: | Pflugers Archiv |
| ISSN: | 1432-2013 0031-6768 |
| Popis: | The giant filamentous protein titin is ideally positioned in the muscle sarcomere to sense mechanical stimuli and transform them into biochemical signals, such as those triggering cardiac hypertrophy. In this review, we ponder the evidence for signaling hotspots along the titin filament involved in mechanosensory control mechanisms. On the way, we distinguish between stress and strain as triggers of mechanical signaling events at the cardiac sarcomere. Whereas the Z-disk and M-band regions of titin may be prominently involved in sensing mechanical stress, signaling hotspots within the elastic I-band titin segment may respond primarily to mechanical strain. Common to both stress and strain sensor elements is their regulation by conformational changes in protein domains. |
| Databáze: | OpenAIRE |
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