Re(VII) and Tc(VII) trioxo complexes stabilized by tridentate ligands and their potential use as radiopharmaceuticals
| Autor: | Eva M. Hahn, Angela Casini, Fritz E. Kuehn |
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| Rok vydání: | 2014 |
| Předmět: |
MAIN-GROUP ELEMENTS
TRANSITION-METALS Stereochemistry MULTIPLE BONDS RHENIUM COMPLEXES OXIDATION-STATE Infrared spectroscopy Coordination complex Inorganic Chemistry chemistry.chemical_compound [3+2] Cycloaddition Transition metal Oxidation state BIOMEDICAL APPLICATIONS Materials Chemistry DOTA Physical and Theoretical Chemistry COORDINATION CHEMISTRY Tridentate ligands chemistry.chemical_classification Chemistry Technetium CROWN THIOETHER CHEMISTRY Cycloaddition Trioxo complexes Rhenium Main group element HIGH-VALENT Radiopharmaceuticals TECHNETIUM COMPLEXES Carbene |
| Zdroj: | Coordination Chemistry Reviews. 276:97-111 |
| ISSN: | 0010-8545 |
| DOI: | 10.1016/j.ccr.2014.05.021 |
| Popis: | Tc(VII) and Re(VII) trioxo complexes are currently arousing interest because of their potential use as radiopharmaceuticals due to their hydrophilic character and stability in a biological environment. The radioactive isotopes Tc-99m and Re-188 are readily obtained from commercially available Mo-99/Tc-99m or W-188/Re-188 generators, respectively. Stabilization of the [MO3](+) species is achieved by coordination of tridentate ligands (N, O, S and Pt donors). Herein, the various synthetic strategies to synthesize these complexes starting from M2O7, [MO4](-), M(+V), M(+III) or M(+I) species are revised. The main structural features of the obtained distorted octahedral metal compounds are presented on the basis of their characterization by NMR and IR spectroscopy, and X-ray crystallography. Interestingly, the [MO3](+) complexes undergo cycloaddition reactions, either to form the corresponding M(+V) diolate complexes via [3 + 2] cycloaddition, or carbene complexes via [2 + 2] cycloaddition. In this review we also comment on the few reported examples using [3 + 2] cycloaddition to label the trioxo compounds with bioactive molecules for their potential application as radiopharmaceuticals. (C) 2014 Elsevier B.V. All rights reserved. |
| Databáze: | OpenAIRE |
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