Group 2 innate lymphoid cells license dendritic cells to potentiate memory TH2 cell responses
| Autor: | Natalio Garbi, Padraic G. Fallon, Timotheus Y.F. Halim, Habib Zaghouani, Andrew N. J. McKenzie, Seth T. Scanlon, You Yi Hwang |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Immunology Cell Mice Transgenic Biology Lymphocyte Activation Article Allergic inflammation 03 medical and health sciences Mice 0302 clinical medicine Th2 Cells medicine Hypersensitivity Immunology and Allergy Animals Lymphocytes Oligonucleotide Array Sequence Analysis Innate immune system Innate lymphoid cell CCL18 Dendritic Cells Acquired immune system Flow Cytometry Immunity Innate 3. Good health B-1 cell Mice Inbred C57BL Disease Models Animal 030104 developmental biology medicine.anatomical_structure Interleukin 13 Immunologic Memory 030215 immunology |
| Zdroj: | Nature immunology |
| ISSN: | 1529-2916 |
| Popis: | Rapid activation of memory CD4(+) T helper 2 (TH2) cells during allergic inflammation requires their recruitment into the affected tissue. Here we demonstrate that group 2 innate lymphoid (ILC2) cells have a crucial role in memory TH2 cell responses, with targeted depletion of ILC2 cells profoundly impairing TH2 cell localization to the lungs and skin of sensitized mice after allergen re-challenge. ILC2-derived interleukin 13 (IL-13) is critical for eliciting production of the TH2 cell-attracting chemokine CCL17 by IRF4(+)CD11b(+)CD103(-) dendritic cells (DCs). Consequently, the sentinel function of DCs is contingent on ILC2 cells for the generation of an efficient memory TH2 cell response. These results elucidate a key innate mechanism in the regulation of the immune memory response to allergens. |
| Databáze: | OpenAIRE |
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