Dynamic enhanced CT: is there a difference between liver metastases of gastroenteropancreatic neuroendocrine tumor and adenocarcinoma
| Autor: | Ying-Shi Sun, Yong Cui, Jie Li, Lei Tang, Zhongwu Li, Shun-Yu Gao, Ying Li, Xiao-Ting Li, Hui-Ci Zhu, Kun Cao |
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| Rok vydání: | 2017 |
| Předmět: |
Oncology
medicine.medical_specialty gastroenteropancreas adenocarcinomas Computed tomography Enhancement pattern Neuroendocrine tumors 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Gastroenteropancreatic neuroendocrine tumor medicine.diagnostic_test business.industry Cancer computed tomography differentiation medicine.disease 030220 oncology & carcinogenesis Adenocarcinoma Christian ministry Radiology neuroendocrine tumors business Dynamic Enhanced CT Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | // Yong Cui 1 , Zhong-Wu Li 2 , Xiao-Ting Li 1 , Shun-Yu Gao 1 , Ying Li 1 , Jie Li 3 , Hui-Ci Zhu 1 , Lei Tang 1 , Kun Cao 1 and Ying-Shi Sun 1 1 Department of Radiology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing 100142, China 2 Department of Pathology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing 100142, China 3 Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing 100142, China Correspondence to: Ying-Shi Sun, email: sys27@163.com Keywords: gastroenteropancreas; neuroendocrine tumors; adenocarcinomas; computed tomography; differentiation Abbreviations: GEP, Gastroenteropancreatic; NETs, Neuroendocrine tumors; CT, Computed tomography Received: March 27, 2017 Accepted: June 18, 2017 Published: November 20, 2017 ABSTRACT This study proposed to evaluate the feasibility of dynamic enhanced CT in differentiation of liver metastases of gastroenteropancreatic well-differentiated neuroendocrine tumors (GEP NETs) from GEP adenocarcinomas based on their characteristic features. CT images of 23 well-differentiated (G1 or G2) GEP NETs and 23 GEP adenocarcinomas patients with liver metastases were retrospectively reviewed. The distribution type, shape, intra-tumoral neovascularity, enhancement on hepatic artery phase, dynamic enhancement pattern and lymphadenopathy were subjective analyzed. Meanwhile, the size, number, CT value of tumor and adjacent normal liver parenchyma were measured and the metastasis-to-liver ratios were calculated objectively. Compared with GEP adenocarcinomas, the liver metastases of GEP NETs more frequently demonstrated a hyper enhancement on hepatic artery phase, washout dynamic enhancement pattern, absence of lymphadenopathy and higher metastasis-to-liver ratios on both hepatic artery phase and portal venous phase ( P =0.017, P |
| Databáze: | OpenAIRE |
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