Cardiovascular risk assessment in prediabetic patients in a hypertensive population: The role of cystatin C
| Autor: | Cristina Soguero-Ruiz, Oscar Barquero-Perez, Rafael Garcia-Carretero, Javier Ramos-Lopez, Inmaculada Mora-Jiménez, Rebeca Goya-Esteban, Luis Vigil-Medina |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Population 030204 cardiovascular system & hematology Risk Assessment Cohort Studies Prediabetic State 03 medical and health sciences 0302 clinical medicine Internal medicine Internal Medicine Electronic Health Records Humans Medicine 030212 general & internal medicine Prediabetes Cystatin C education Aged education.field_of_study biology Proportional hazards model business.industry Hazard ratio Age Factors General Medicine Middle Aged medicine.disease Cardiovascular Diseases Population Surveillance Hypertension Cohort biology.protein Female business Risk assessment Biomarkers Follow-Up Studies Cohort study |
| Zdroj: | Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 12:625-629 |
| ISSN: | 1871-4021 |
| Popis: | The aim of our study was to determine whether prediabetes increases cardiovascular (CV) risk compared to the non-prediabetic patients in our hypertensive population. Once this was achieved, the objective was to identify relevant CV prognostic features among prediabetic individuals.We included hypertensive 1652 patients. The primary outcome was a composite of incident CV events: cardiovascular death, stroke, heart failure and myocardial infarction. We performed a Cox proportional hazard regression to assess the CV risk of prediabetic patients compared to non-prediabetic and to produce a survival model in the prediabetic cohort.The risk of developing a CV event was higher in the prediabetic cohort than in the non-prediabetic cohort, with a hazard ratio (HR) = 1.61, 95% CI 1.01-2.54, p = 0.04. Our Cox proportional hazard model selected age (HR = 1.04, 95% CI 1.02-1.07, p 0.001) and cystatin C (HR = 2.4, 95% CI 1.26-4.22, p = 0.01) as the most relevant prognostic features in our prediabetic patients.Prediabetes was associated with an increased risk of CV events, when compared with the non-prediabetic patients. Age and cystatin C were found as significant risk factors for CV events in the prediabetic cohort. |
| Databáze: | OpenAIRE |
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