TFG: a novel regulator of ULK1-dependent autophagy

Autor:	Francesca Nazio, Francesco Cecconi
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Omegasome Cancer Research Settore BIO/06 Kinase Autophagy neurological disorders Regulator TFG omegasome Biology ULK1 ERGIC medicine.disease_cause Immunoglobulin light chain Cell biology medicine Author’s Views Molecular Medicine Carcinogenesis Gene Article Commentary
Zdroj:	Molecular & Cellular Oncology article-version (VoR) Version of Record
ISSN:	2372-3556
Popis:	TRK-fused gene (TFG) is a protein implicated in multiple neurodegenerative diseases and oncogenesis. We have recently shown that, under starvation conditions, TFG contributes to spatial control of autophagy by facilitating Unc-51 like autophagy activating kinase 1 (ULK1)-microtubule-associated protein 1 light chain 3 gamma (MAP1LC3C) interaction to modulate omegasome and autophagosome formation. Defective TFG-mediated autophagy could thus be postulated as a possible contributor to ontogenesis or progression of TFG-related diseases.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2fd521c1302aa2aad5a6fe15ae33e86 http://europepmc.org/articles/PMC8489955 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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