Comparative Human Cellular Radiosensitivity: III. γ-radiation Survival of Cultured Skin Fibroblasts and Resting T-lymphocytes from the Peripheral Blood of the Same Individual
| Autor: | S.A. Harcourt, C.F. Arlett, G. A. Shun-Shin, D.M. Beare, N.A.P. Brown, Michael H.L. Green, A. Priestley, G. Stephens, J. Cole, A. P. W. Waugh |
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| Rok vydání: | 1991 |
| Předmět: |
Male
Pathology medicine.medical_specialty Cell type Radiobiology Cell Survival T-Lymphocytes Biology Radiation Tolerance medicine Humans Radiology Nuclear Medicine and imaging Radiosensitivity Cobalt Radioisotopes Fibroblast Skin Radiological and Ultrasound Technology Dose-Response Relationship Radiation T lymphocyte Fibroblasts Middle Aged In vitro Peripheral blood medicine.anatomical_structure Gamma Rays Cell culture Cancer research |
| Zdroj: | International Journal of Radiation Biology. 59:749-765 |
| ISSN: | 1362-3095 0955-3002 |
| DOI: | 10.1080/09553009114550661 |
| Popis: | SummarySkin and blood samples were obtained from 34 donors, for whom there was no indication of abnormal radiosensitivity. From these, in 33 cases both fibroblast and T-lymphocyte cultures were obtained and in 26 cases at least three fibroblast and at least two G0 (resting) T-lymphocyte survival assays were possible. Within this set of results, differences in radiosensitivity between donors were significant for fibroblasts but not T-lymphocytes, although the range of radiosensitivity was similar for the two cell types (D¯ 0·90–1·68 Gy for fibroblasts; 1·26–2·15 Gy for T-lymphocytes). Furthermore, there was little evidence for a correlation in radiosensitivity between the two cell types. These results suggest limitations in the predictive value of conventional measurement of cell survival. |
| Databáze: | OpenAIRE |
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