MXene-Based Hydrogels Endow Polyetheretherketone with Effective Osteogenicity and Combined Treatment of Osteosarcoma and Bacterial Infection
| Autor: | Junchuan Zhang, Qiuyang Han, Xueqi Gan, Lu Xie, Jie Yin, Kenan Xie, Yi Deng, Yunxiu Liu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Materials science
Cell Survival Photothermal Therapy Polymers Surface Properties Antineoplastic Agents Bone Neoplasms Mice Inbred Strains Microbial Sensitivity Tests 02 engineering and technology Gram-Positive Bacteria 010402 general chemistry 01 natural sciences Osseointegration Polyethylene Glycols Rats Sprague-Dawley Benzophenones Mice Osteogenesis In vivo Gram-Negative Bacteria medicine Animals Humans General Materials Science Particle Size Cells Cultured Cell Proliferation Osteosarcoma Cell Differentiation Hydrogels 3T3 Cells Ketones Cell cycle Photothermal therapy 021001 nanoscience & nanotechnology medicine.disease Anti-Bacterial Agents Rats 0104 chemical sciences Self-healing hydrogels Alkaline phosphatase Implant Drug Screening Assays Antitumor 0210 nano-technology Biomedical engineering |
| Zdroj: | ACS Applied Materials & Interfaces. 12:45891-45903 |
| ISSN: | 1944-8252 1944-8244 |
| Popis: | After an osteosarcoma resection, the risks of cancer recurrence, postoperative infection, and large bone loss still threaten patients' health. Conventional treatment relies on implanting orthopedic materials to fill bone defects after surgery, but it has no ability of destroying residual tumor cells and preventing bacterial invasion. To tackle this challenge, here, we develop a novel multifunctional implant (SP@MX/GelMA) that mainly consists of MXene nanosheets, gelatin methacrylate (GelMA) hydrogels, and bioinert sulfonated polyetheretherketone (SP) with the purpose of facilitating tumor cell death, combating pathogenic bacteria, and promoting osteogenicity. Because of the synergistic photothermal effects of MXene and polydopamine (pDA), osteosarcoma cells are effectively killed on the multifunctional coatings under 808 nm near-infrared (NIR) irradiation through thermal ablation. After loading tobramycin (TOB), the SP@MX-TOB/GelMA implants display robust antibacterial properties against Gram-negative/Gram-positive bacteria. More importantly, the multifunctional implants are demonstrated to have superior cytocompatibility and osteogenesis-promoting capability in terms of cell replication, spreading, alkaline phosphatase activity, calcium matrix mineralization, and in vivo osseointegration. Accordingly, such photothermally controlled multifunctional implants not only defeat osteosarcoma cells and bacteria but also intensify osteogenicity, which hold a greatly promising countermeasure for curing postoperative tissue lesion from an osteosarcoma excision. |
| Databáze: | OpenAIRE |
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