LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein
| Autor: | Mario Chojkier, Eileen Elisabeth Falvey, Patrick Descombes, Ulrich Schibler, Serge Patrick Lichtsteiner |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1990 |
| Předmět: |
Male
Leucine zipper Transcription Genetic Molecular Sequence Data DNA-binding protein Chimeric gene Biology Gene product Transcriptional activation Complementary DNA Albumins Sequence Homology Nucleic Acid ddc:570 Genetics Gene family Animals Amino Acid Sequence Cloning Molecular Promoter Regions Genetic Peptide sequence Cell Nucleus Ccaat-enhancer-binding proteins Base Sequence Models Genetic digestive oral and skin physiology C/EBP equipment and supplies Molecular biology Rats DNA-Binding Proteins Enhancer Elements Genetic Liver Organ Specificity Rats Inbred Lew LAP CCAAT-Enhancer-Binding Proteins human activities Developmental Biology Protein Binding Transcription Factors |
| Zdroj: | Genes and Development, Vol. 4, No 9 (1990) pp. 1541-1551 |
| ISSN: | 0890-9369 |
| Popis: | A gene, encoding a liver-enriched transcriptional activator protein (LAP) has been isolated. LAP is a 32-kD protein that stimulates the transcription of chimeric genes containing albumin D-promoter elements both in vivo and in vitro. LAP shares extensive sequence homology (71%) in its DNA-binding and leucine zipper domains with C/EBP. As a consequence, these two proteins show an indistinguishable DNA-binding specificity and readily heterodimerize. In addition, both genes, lap and cebp, are devoid of intervening sequences. Although correctly initiated transcripts from the LAP gene accumulate in the six examined tissues--liver, lung, spleen, kidney, brain, and testis--LAP protein is highly enriched in liver nuclei. Thus, the preferential accumulation of LAP protein in liver appears to be regulated post-transcriptionally. |
| Databáze: | OpenAIRE |
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