Pharos: Collating protein information to shed light on the druggable genome
| Autor: | Rajarshi Guha, Anne Hersey, Nicolas F. Fernandez, Anna Waller, Lars Juhl Jensen, Juhee Patel, John P. Overington, Larry A. Sklar, Geetha Mandava, Dac-Trung Nguyen, Ajit Jadhav, Søren Brunak, Saurabh Mehta, Jeremy J. Yang, Subramani Mani, Noel Southall, Timothy Sheils, Guixia Liu, Dusica Vidovic, Cristian Bologa, Anneli Karlsson, Anna Gaulton, Avi Ma'ayan, Stephan C. Schürer, Tudor I. Oprea, Jayme Holmes, Oleg Ursu, Andrew D. Rouillard, Stephen L. Mathias, Anton Simeonov |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Interface (Java) Druggability Genomics Biology Web Browser Genome World Wide Web 03 medical and health sciences 0302 clinical medicine Resource (project management) Databases Genetic Drug Discovery Genetics Database Issue Cluster Analysis Humans Use case Obesity Computational Biology Search Engine 030104 developmental biology Pharmacogenetics User interface Relevant information 030217 neurology & neurosurgery Software |
| Zdroj: | Nucleic Acids Research |
| ISSN: | 1362-4962 0305-1048 |
| Popis: | The 'druggable genome' encompasses several protein families, but only a subset of targets within them have attracted significant research attention and thus have information about them publicly available. The Illuminating the Druggable Genome (IDG) program was initiated in 2014, has the goal of developing experimental techniques and a Knowledge Management Center (KMC) that would collect and organize information about protein targets from four families, representing the most common druggable targets with an emphasis on understudied proteins. Here, we describe two resources developed by the KMC: the Target Central Resource Database (TCRD) which collates many heterogeneous gene/protein datasets and Pharos (https://pharos.nih.gov), a multimodal web interface that presents the data from TCRD. We briefly describe the types and sources of data considered by the KMC and then highlight features of the Pharos interface designed to enable intuitive access to the IDG knowledgebase. The aim of Pharos is to encourage 'serendipitous browsing', whereby related, relevant information is made easily discoverable. We conclude by describing two use cases that highlight the utility of Pharos and TCRD. |
| Databáze: | OpenAIRE |
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