Differential impacts of late gestational over- and undernutrition on adipose tissue traits and associated visceral obesity risk upon exposure to a postnatal high‐fat diet in adolescent sheep
| Autor: | Haja N. Kadarmideen, Sharmila Binti Ahmad, Sina Safayi, Deepak Pandey, Prabhat Khanal, Mette Olaf Nielsen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Physiology Adipose tissue Inflammation Fetal Nutrition Disorders Intra-Abdominal Fat 030204 cardiovascular system & hematology Diet High-Fat Landbruks- og Fiskerifag: 900::Landbruksfag: 910::Husdyravl oppdrett forplantning: 912 [VDP] lcsh:Physiology Muscle hypertrophy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine SDG 3 - Good Health and Well-being cellularity Physiology (medical) Adipocyte Internal medicine Animals Medicine Obesity adipocyte tissue SDG 2 - Zero Hunger Original Research Adiposity Sheep lcsh:QP1-981 business.industry hyperplasia Lipid metabolism Hyperplasia Lipid Metabolism medicine.disease Malnutrition Endocrinology fetal programming chemistry Matematikk og Naturvitenskap: 400::Basale biofag: 470::Genetikk og genomikk: 474 [VDP] Gestation Female Landbruks- og Fiskerifag: 900::Landbruksfag: 910::Fôring: 918 [VDP] medicine.symptom business hypertrophy 030217 neurology & neurosurgery |
| Zdroj: | Physiological Reports e14359 Khanal, P, Pandey, D, Binti Ahmad, S, Safayi, S, Kadarmideen, H N & Olaf Nielsen, M 2020, ' Differential impacts of late gestational over-and undernutrition on adipose tissue traits and associated visceral obesity risk upon exposure to a postnatal high-fat diet in adolescent sheep ', Physiological Reports, vol. 8, no. 3, e14359 . https://doi.org/10.14814/phy2.14359 Khanal, P, Pandey, D, Binti Ahmad, S, Safayi, S, Kadarmideen, H N & Nielsen, M O 2020, ' Differential impacts of late gestational over-and undernutrition on adipose tissue traits and associated visceral obesity risk upon exposure to a postnatal high-fat diet in adolescent sheep ', Physiological Reports, vol. 8, no. 3, e14359 . https://doi.org/10.14814/phy2.14359 Physiological Reports, Vol 8, Iss 3, Pp n/a-n/a (2020) Khanal, P, Pandey, D, Binti Ahmad, S, Safayi, S, Kadarmideen, H N & Olaf Nielsen, M 2020, ' Differential impacts of late gestational over–and undernutrition on adipose tissue traits and associated visceral obesity risk upon exposure to a postnatal high-fat diet in adolescent sheep ', Physiological Reports, vol. 8, no. 3, e14359 . https://doi.org/10.14814/phy2.14359 |
| Popis: | We hypothesized that late gestation malnutrition differentially affects expandability of adipose tissues to predispose for early postnatal visceral adiposity. Twin‐lambs born to dams fed HIGH (150%/110% of required energy/protein, respectively), NORM (100% of requirements) or LOW (50% of NORM) diets during the last trimester were used. Postnatally, lambs were raised on moderate (CONV) or high‐carbohydrate‐high‐fat (HCHF) diets. Adipose tissues were sampled at autopsy at 6 months of age (~puberty) to characterize cellularity, adipocyte cross‐sectional area and gene expression patterns. HIGH and LOW compared to NORM lambs had reduced intrinsic (under CONV diet) cellularity in subcutaneous and mesenteric (particularly LOW), and reduced obesity‐induced (under HCHF diet) hyperplasia in subcutaneous, mesenteric and perirenal (particularly HIGH) adipose tissues. This corresponded with more pronounced HCHF diet‐induced hypertrophy in mesenteric (particularly LOW), perirenal (particularly HIGH) and subcutaneous (particularly HIGH) adipose tissues, and tissue‐specific reductions in mRNA expressions for lipid metabolism, angiogenesis and adipose development. Gene expression for inflammation and lipid metabolism markers were increased and decreased, respectively, in HCHF lambs (HCHF lambs became obese) in all tissues. Both prenatal over‐ and undernutrition predisposed for abdominal adiposity and extreme perirenal hypertrophy due to reduced intrinsic (observed under CONV diet) cellularity and impaired ability of subcutaneous, mesenteric and perirenal adipose tissues to expand by hyperplasia rather than hypertrophy on an obesogenic (HCHF) diet. Both prenatal over‐ and undernutrition predisposes for abdominal adiposity and extreme perirenal hypertrophy due to reduced intrinsic cellularity and impaired ability of subcutaneous, mesenteric and perirenal adipose tissues to expand by hyperplasia rather than hypertrophy. |
| Databáze: | OpenAIRE |
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