Apelinergic system in endothelial cells and its role in angiogenesis in myocardial ischemia
| Autor: | Martin Klabusay, Gurpreet S. Sandhu, Vera Novakova, Dan Dragomir-Daescu |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Physiology Angiogenesis Cell Myocardial Infarction Myocardial Ischemia Neovascularization Physiologic 03 medical and health sciences Internal medicine medicine Animals Humans Myocardial infarction Pharmacology Tube formation Neovascularization Pathologic business.industry Intracellular Signaling Peptides and Proteins Endothelial Cells medicine.disease Apelin 030104 developmental biology Endocrinology medicine.anatomical_structure Cancer research Molecular Medicine Pericyte Signal transduction business Signal Transduction Blood vessel |
| Zdroj: | Vascular Pharmacology. 76:1-10 |
| ISSN: | 1537-1891 |
| Popis: | Apelin is a peptide known to have a vital role in cardiovascular diseases. It has been proven to induce proliferation and tube formation in endothelial cells, stabilise contacts between endothelial cells, and mediate pericyte recruitment. Since apelin level is reduced early after myocardial infarction, a supportive therapy with apelin is being investigated for its beneficial effect on blood vessel formation. It is becoming apparent, however, that the final effect of apelin often depends on stimuli the cell receives and the cross-talk with other molecules inside the cell. Hence, understanding the apelin pathway potentially can help us to improve angiogenic therapy. This review summarises recent knowledge regarding molecules involved in apelin signalling while focusing on their roles in angiogenesis within the ischemic environment after myocardial infarction. |
| Databáze: | OpenAIRE |
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