Cytogenetics of myelodysplasia and acute myeloid leukaemia in aircrew and people treated with radiotherapy

Autor:	Vilhjalmur Rafnsson, Hans H. Storm, Jens Pedersen-Bjergaard, Maryanne Gundestrup, Erla Sveinbjornsdottir, Mette K. Andersen
Rok vydání:	2000
Předmět:	Adult Male Oncology medicine.medical_specialty Pathology medicine.medical_treatment Pathogenesis hemic and lymphatic diseases Internal medicine medicine Humans Radiation Injuries Aged Chromosome 7 (human) business.industry Cytogenetics Karyotype General Medicine Middle Aged Radiation therapy Increased risk Myelodysplastic Syndromes Female Aircrew Myeloid leukaemia business Chromosomes Human Pair 7 Gene Deletion
Zdroj:	The Lancet. 356:2158
ISSN:	0140-6736
DOI:	10.1016/s0140-6736(00)03501-7
Popis:	Increased risk of acute myeloid leukaemia has been reported in aircrew, possibly in association with cosmic radiation. We studied the cytogenetics of seven aircrew members who had acute myeloid leukaemia or myelodysplasia and found deletion or loss of chromosome 7 in four. The same abnormality was found in eight of 19 patients with leukaemia after radiotherapy alone. By comparison, only 81 of 761 unselected cases of myelodysplasia or acute myeloid leukaemia had the same cytogenetic abnormalities. Our results support the concept that deletions or loss of the long arm of chromosome 7 in myelodysplasia and acute myeloid leukaemia could indicate previous exposure to ionising radiation.
Databáze:	OpenAIRE
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