MK-801, a non-competitive NMDA receptor antagonist, produces facilitation of the micturition reflex in awake, freely-moving rats
| Autor: | I. Nadelhaft, Pedro L. Vera |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
media_common.quotation_subject Urinary Bladder Urination Receptors N-Methyl-D-Aspartate Urethane Internal medicine Reflex medicine Animals Wakefulness Receptor Anesthetics media_common Dose-Response Relationship Drug Chemistry General Neuroscience Glutamate receptor Muscle Smooth Rats Inbred Strains Stimulation Chemical Rats Dizocilpine Endocrinology Anesthetic NMDA receptor Female Dizocilpine Maleate medicine.symptom Muscle Contraction medicine.drug Muscle contraction |
| Zdroj: | Neuroscience Letters. 134:135-138 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/0304-3940(91)90525-x |
| Popis: | MK-801 (dizocilpine), a non-competitive N-methyl-D-aspartate (NMDA) receptor blocker, produced a dose-dependent (30-120 micrograms/kg, i.v.) increase in the frequency of micturition (as well as the already described behavioral effects) in awake, freely-moving rats. The contraction amplitude was also slightly increased. In contrast, MK-801 administered to urethane-anesthetized rats resulted in complete inhibition of bladder contractions. The effect of MK-801 on the frequency of bladder contractions, therefore, is anesthetic dependent. Excitatory amino acids acting at NMDA receptors may play a role in the control of micturition. |
| Databáze: | OpenAIRE |
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