201Tl scintigraphy does not allow visualization of the thyroid in euthyroid and hyperthyroid patients treated with amiodarone
| Autor: | K. Van Laere, Myriam Monsieurs, C. Van de Wiele, J. M. Kaufman, K Osmanagaoglu, R. A. J. O. Dierckx |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Male medicine.medical_specialty Pertechnetate Urology Thyroid Gland chemistry.chemical_element Amiodarone Technetium Scintigraphy Thyroid function tests Hyperthyroidism chemistry.chemical_compound Reference Values Medicine Humans Radiology Nuclear Medicine and imaging Euthyroid Radionuclide Imaging Parathyroid adenoma Aged Retrospective Studies Sodium Pertechnetate Tc 99m Aged 80 and over medicine.diagnostic_test business.industry Thyroid Arrhythmias Cardiac General Medicine Middle Aged medicine.disease Thallium Radioisotopes medicine.anatomical_structure chemistry Female business Nuclear medicine Anti-Arrhythmia Agents medicine.drug |
| Zdroj: | Nuclear medicine communications. 18(6) |
| ISSN: | 0143-3636 |
| Popis: | A retrospective study was performed to evaluate the usefulness of thallium scintigraphy for visualization of thyroid morphology and function. Moreover, applying absolute quantitation, we wished to confirm the qualitatively reduced 99Tc(m) uptake reported by Wiersinga et al. in both euthyroid and hyperthyroid patients treated with amiodarone. Over a period of 2 years (1995-96), 10 patients (group A; 2 females, 8 males, mean age 68.6 years, range 61-74 years) receiving amiodarone treatment for cardiac arrhythmias for at least 4 months were referred for exploration of either hyperthyroidism (n = 4) or for exclusion of parathyroid adenoma (n = 6). During the same period, 17 patients (group B; 10 females, 7 males, mean age 62 years, range 19-91 years) referred for Tc-Tl subtraction scintigraphy, and in whom follow-up revealed no thyroid or parathyroid pathology, were used as controls. In all patients, thyroid status was assessed by thyroid function tests. 201Tl and 99Tc(m) uptake was calculated as a percentage of the injected dose, taking account of net injected counts and background and isotope decay correction. Original images were scored using a 2-point scoring system (0 = poor, 1 = fair or good). Uptake of both 99Tc(m) and 201Tl was significantly reduced in group A (99Tc[m]: 0.16 +/- 0.21%; 201Tl: 0.30 +/- 0.21%; mean +/- S.D.) compared to group B (99Tc[m]: 1.58 +/- 1.07%; 201Tl: 0.72 +/- 0.37%) (P < 0.005). The mean relative reduction in 99Tc(m) uptake was more pronounced (90% decrease) than that of 201Tl (58% decrease). In group A, the 99Tc(m) and 201Tl image quality was poor in 10 of 10 and 8 of 10 patients respectively. In group B, the 99Tc(m) and 201Tl image quality was poor in 3 of 17 and 4 of 17 patients respectively. The decreased uptake of 201Tl may reflect the inhibitory effect of iodides on adenyl cyclase and its stimulation by TSH. In conclusion, the data presented confirm the qualitatively reduced pertechnetate uptake reported by Wiersinga et al. Furthermore, 201Tl uptake by the thyroid in euthyroid or hyperthyroid patients treated with amiodarone is also reduced. Although quantitatively less pronounced, it does not allow proper visualization of the thyroid. |
| Databáze: | OpenAIRE |
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