Chronic kidney disease exacerbates ischemic limb myopathy in mice via altered mitochondrial energetics
| Autor: | Trace Thome, Ravi A. Kumar, Leonardo F. Ferreira, Scott A. Berceli, Sarah E. Gray, Fabian N. Berru, Kerri A. O’Malley, Terence E. Ryan, Salvatore T. Scali, Madeline Coleman, Zachary R. Salyers, Dennis Le |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Renal function lcsh:Medicine 030204 cardiovascular system & hematology medicine.disease_cause urologic and male genital diseases Article 03 medical and health sciences Mice 0302 clinical medicine Atrophy Muscular Diseases Ischemia Internal medicine Chronic kidney disease medicine Myocyte Animals Humans Renal Insufficiency Chronic Myopathy Muscle Skeletal lcsh:Science Blood urea nitrogen Kidney Multidisciplinary business.industry lcsh:R medicine.disease female genital diseases and pregnancy complications 3. Good health Hindlimb Mitochondria Muscle Oxidative Stress 030104 developmental biology medicine.anatomical_structure Endocrinology Peripheral vascular disease Female lcsh:Q medicine.symptom business Oxidative stress Kidney disease |
| Zdroj: | Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019) Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-019-52107-7 |
| Popis: | Chronic kidney disease (CKD) substantially increases the severity of peripheral arterial disease (PAD) symptomology, however, the biological mechanisms remain unclear. The objective herein was to determine the impact of CKD on PAD pathology in mice. C57BL6/J mice were subjected to a diet-induced model of CKD by delivery of adenine for six weeks. CKD was confirmed by measurements of glomerular filtration rate, blood urea nitrogen, and kidney histopathology. Mice with CKD displayed lower muscle force production and greater ischemic lesions in the tibialis anterior muscle (78.1 ± 14.5% vs. 2.5 ± 0.5% in control mice, P 2 vs. 2221 ± 100 μm2 in control mice, P |
| Databáze: | OpenAIRE |
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