HIV-associated neurodegeneration and neuroimmunity: multivoxel MR spectroscopy study in drug-naïve and treated patients

Autor:	Dajana Lendak, Jelena Ostojic, Jasmina Boban, Dusko Kozic, Snezana Brkic, Vesna Turkulov, Robert Semnic
Rok vydání:	2017
Předmět:	Adult Male 0301 basic medicine Cart In vivo magnetic resonance spectroscopy medicine.medical_specialty Pathology AIDS Dementia Complex Magnetic Resonance Spectroscopy HIV Infections Gastroenterology Choline White matter Young Adult 03 medical and health sciences 0302 clinical medicine Gyrus Internal medicine Humans Medicine Radiology Nuclear Medicine and imaging Retrospective Studies Aspartic Acid business.industry Neurodegeneration Brain virus diseases Neurodegenerative Diseases General Medicine Human brain Middle Aged Creatine medicine.disease White Matter Drug-naïve 030104 developmental biology medicine.anatomical_structure nervous system Case-Control Studies Brain size Female Radiology business Biomarkers 030217 neurology & neurosurgery medicine.drug
Zdroj:	European Radiology. 27:4218-4236
ISSN:	1432-1084 0938-7994
Popis:	The aim of this study was to test neurobiochemical changes in normal appearing brain tissue in HIV+ patients receiving and not receiving combined antiretroviral therapy (cART) and healthy controls, using multivoxel MR spectroscopy (mvMRS). We performed long- and short-echo 3D mvMRS in 110 neuroasymptomatic subjects (32 HIV+ subjects on cART, 28 HIV+ therapy-naive subjects and 50 healthy controls) on a 3T MR scanner, targeting frontal and parietal supracallosal subcortical and deep white matter and cingulate gyrus (NAA/Cr, Cho/Cr and mI/Cr ratios were analysed). The statistical value was set at p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2f58f7f9cff4b937e172b37289c5137 https://doi.org/10.1007/s00330-017-4772-5 Zobrazit plný text záznamu Full text from SpringerLink