Expression of LncRNAs in HPV-induced Carcinogenesis and Cancer Cachexia: A Study in K14-HPV16 Mice
| Autor: | TÂNIA R. DIAS, JOANA M. O. SANTOS, DIOGO ESTÊVÃO, NATÁLIA R. COSTA, VERÓNICA F. MESTRE, BEATRIZ MEDEIROS-FONSECA, MARGARIDA M.S.M. BASTOS, PAULA A. OLIVEIRA, RUI M. GIL DA COSTA, RUI MEDEIROS |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Anticancer Research. 42:2443-2460 |
| ISSN: | 1791-7530 0250-7005 |
| DOI: | 10.21873/anticanres.15723 |
| Popis: | To evaluate the expression of lincRNA-p21, H19, EMX2OS, SNHG12 and MALAT1 in a mouse model of human papillomavirus 16 (HPV16)-induced carcinogenesis and cachexia.Chest skin, ear, tongue, penis and gastrocnemius muscle samples from wild-type mice (HPV-) and K14-HPV16 male mice (HPV+) were collected to evaluate the expression of the selected lncRNAs using real-time PCR (qPCR).In chest skin and ear, H19, SNHG12, EMX2OS and lincRNA-p21 were down-regulated in HPV+ versus HPV- mice. In tongue and penile tissues, there was only down-regulation of lincRNA-p21 in HPV+ mice. Additionally, in penile tissue, lincRNA-p21 expression decreased in HPV-induced lesions comparing with normal tissues. In gastrocnemius muscle, MALAT1 was up-regulated and lincRNA-p21 was down-regulated in HPV+ versus HPV-mice.H19, SNHG12, EMX2OS and lincRNA-p21 may be involved in HPV-induced carcinogenesis. In addition, MALAT1 and lincRNA-p21 may play a role in muscle wasting and contribute to cancer cachexia. |
| Databáze: | OpenAIRE |
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