Patterns of endogenous steroids in apathetic refugee children are compatible with long-term stress

Autor: Bernice Aronsson, Mark M. Kushnir, Jonas Bergquist, Hans Peter Söndergaard, Per Sandstedt
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Male
Medicin och hälsovetenskap
Time Factors
Hydrocortisone
lcsh:Medicine
Apathetic refugee children
Medical and Health Sciences
Mass Spectrometry
Cortisol
Activities of Daily Living
Child
lcsh:QH301-705.5
Medicine(all)
Refugees
Unconscious
Psychology
17-alpha-Hydroxyprogesterone
Traumatic stress
Syndrome
General Medicine
Factitious disorder
Pregnenolone
Female
Steroids
Neurosteroids
Research Article
medicine.drug
medicine.medical_specialty
Neuroactive steroid
Adolescent
Dehydroepiandrosterone
General Biochemistry
Genetics and Molecular Biology
Internal medicine
medicine
Humans
Dissociative disorders
lcsh:Science (General)
Sweden
Mass spectrometry
business.industry
Biochemistry
Genetics and Molecular Biology(all)
lcsh:R
Kemi
medicine.disease
Cortisone
Endocrinology
lcsh:Biology (General)
Chemical Sciences
business
Stress
Psychological
lcsh:Q1-390
Chromatography
Liquid
Zdroj: BMC Research Notes
BMC Research Notes, Vol 5, Iss 1, p 186 (2012)
Popis: Background During the last few years, a number of children of asylum applicants in Sweden developed an apathetic or unconscious state. The syndrome was perceived as new, and various explanations were advanced such as factitious disorder, intoxication, or stress. Considering a potential association between traumatic stress and regulation of steroids biosynthesis, this study explored whether changes in concentrations of endogenous steroids were associated with the above syndrome. Methods Eleven children were recruited in the study. Concentrations of steroids in blood samples were determined using high sensitivity liquid chromatography tandem mass spectrometry methods. Symptoms were assessed with a clinical rating scale developed for the study. Steroid concentrations were measured at the entry into study and after recovery; and concentrations were evaluated for the association with the symptoms in apathetic children. Results Cortisol and cortisone concentrations at baseline were negatively associated with duration of the symptoms from entry into the study to clinical recovery. Higher concentrations of pregnanes (pregnenolone, 17-OH-pregnenolone, and dehydroepiandrosterone) were observed in the symptomatic state and the concentrations decreased after the recovery. Conclusions Pattern of low cortisol concentrations found in apathetic children is consistent with long-term stress. An increase of upstream steroid metabolites (pregnanes) was found to be associated with the symptomatic state.
Databáze: OpenAIRE
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