Effects of valproic acid on an animal model of tardive dyskinesia
| Autor: | Regina H. Silva, Vanessa C. Abílio, Marcello F. Peixoto, Roberto Frussa-Filho |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Dyskinesia Drug-Induced Reserpine GABA Agents Central nervous system Tardive dyskinesia Behavioral Neuroscience Internal medicine Basal ganglia medicine Animals Rats Wistar Valproic Acid Analysis of Variance Dose-Response Relationship Drug Antagonist medicine.disease Pathophysiology Rats Disease Models Animal medicine.anatomical_structure Endocrinology Dyskinesia Exploratory Behavior medicine.symptom Psychology medicine.drug |
| Zdroj: | Behavioural brain research. 142(1-2) |
| ISSN: | 0166-4328 |
| Popis: | GABAergic hypofunction in the basal ganglia is stated as an important mechanism underlying the pathophysiology of tardive dyskinesia. The present study investigates the effects of the GABA-mimetic drug valproic acid (VA) on the manifestation of reserpine-induced orofacial movements, an animal model of tardive dyskinesia. Male Wistar rats received two injections of control solution or of 1 mg/kg reserpine separated by 48 h. Twenty-four hours later, animals were acutely treated with 50, 100, or 200 mg/kg VA or control solution and were observed for quantification of orofacial movements and of open-field general activity. The highest dose of VA inhibited the manifestation of reserpine-induced orofacial movements but none of the VA doses modified reserpine-induced decrease in open-field general activity. These results support the potential of VA as an effective pharmacological tool in the treatment of tardive dyskinesia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect