Increased angiogenic sprouting in poor prognosis FL is associated with elevated numbers of CD163+ macrophages within the immediate sprouting microenvironment
| Autor: | Kelly J. Morris, Alan G. Ramsay, Andrew Clear, Maria Calaminici, Finlay MacDougall, Abigail M. Lee, Gavin Kelly, T. Andrew Lister, John G. Gribben, Simon Hallam |
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| Rok vydání: | 2010 |
| Předmět: |
Pathology
medicine.medical_specialty Angiogenesis Biopsy Immunology Follicular lymphoma Antigens Differentiation Myelomonocytic Receptors Cell Surface Biology Biochemistry Neovascularization Antigens CD Biomarkers Tumor medicine Humans Lymphoma Follicular Lymphoid Neoplasia Tissue microarray Neovascularization Pathologic medicine.diagnostic_test Macrophages Cell Biology Hematology Prognosis medicine.disease Lymphoma Platelet Endothelial Cell Adhesion Molecule-1 cardiovascular system medicine.symptom CD163 Sprouting |
| Zdroj: | Blood. 115:5053-5056 |
| ISSN: | 1528-0020 0006-4971 |
| DOI: | 10.1182/blood-2009-11-253260 |
| Popis: | Follicular lymphoma has considerable clinical heterogeneity, and there is a need for easily quantifiable prognostic biomarkers. Microvessel density has been shown to be a useful prognostic factor based on numerical assessment of vessel numbers within histologic sections in some studies, but assessment of tumor neovascularization through angiogenic sprouting may be more relevant. We therefore examined the smallest vessels, single-staining structures measuring less than 30 μm2 in area, seen within histologic sections, and confirmed that they were neovascular angiogenic sprouts using extended focal imaging. Tissue microarrays composing diagnostic biopsies from patients at the extremes of survival of follicular lymphoma were analyzed with respect to numbers of these sprouts. This analysis revealed higher angiogenic activity in the poor prognostic group and demonstrated an association between increased sprouting and elevated numbers of infiltrating CD163+ macrophages within the immediate microenvironment surrounding the neovascular sprout. |
| Databáze: | OpenAIRE |
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