Utilization of Stabilized Forms of Polynucleotides
| Autor: | Freddie L. Riley, Hilton B. Levy |
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| Rok vydání: | 1983 |
| Předmět: | |
| Zdroj: | Polymers in Medicine ISBN: 9781461576457 Interferons and Their Applications ISBN: 9783642691805 |
| DOI: | 10.1007/978-1-4615-7643-3_3 |
| Popis: | Within a few years after the description of interferon by Isaacs and Lindenmann (1957), it was recognized that interferon potentially was a broad-spectrum antiviral agent of possibly high value in clinical medicine. However, the difficulty of preparing enough interferon, either nonhuman or human, prevented the adequate testing of this potentiality. Serious efforts were made to find nonreplicating agents that would cause the host to synthesize its own interferon in large quantity. While a number of compounds were found that are capable of causing mice, and possibly humans, to make interferon, they either induced too small amounts or were too toxic (Merigan 1973). Field et al. (1967) reported that a number of natural and synthetic double-stranded (ds) RNAs are capable of inducing interferon. In particular, the dsRNA polyinosinic-polycytidylic acid (poly(I)-poly(C)) was highly effective in rodents as an interferon inducer (Field et al. 1967), as an antiviral agent (Parks and Baron 1968; Worthington et al. 1973) and as an antitumor agent (Zelezinck and Bhuyan 1969; Levy et al. 1969). |
| Databáze: | OpenAIRE |
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