Effectiveness of Olanzapine Combined with Ondansetron in Prevention of Chemotherapy-Induced Nausea and Vomiting of Non-small Cell Lung Cancer
| Autor: | Lei Wang, Huayong Wang, Hao Zhang, Xin Wang |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Olanzapine Lung Neoplasms Vomiting Nausea medicine.drug_class medicine.medical_treatment Biophysics Antineoplastic Agents Biochemistry Ondansetron Benzodiazepines Carcinoma Non-Small-Cell Lung medicine Humans Antiemetic Lung cancer Aged Chemotherapy business.industry Cell Biology General Medicine Middle Aged medicine.disease Drug Combinations Anesthesia Antiemetics Female medicine.symptom business medicine.drug Chemotherapy-induced nausea and vomiting |
| Zdroj: | Cell Biochemistry and Biophysics. 72:471-473 |
| ISSN: | 1559-0283 1085-9195 |
| DOI: | 10.1007/s12013-014-0489-0 |
| Popis: | The objective of this study is to compare the effectiveness of olanzapine combined with ondansetron or ondansetron alone in preventing chemotherapy-induced nausea and vomiting (CINV) of non-small cell lung cancer (NSCLC). A total of 84 NSCLC patients were equally randomized into intervention group and control group. Both groups were intravenously administered with ondansetron 8 mg 30 min before chemotherapy. In the intervention group, olanzapin 10 mg was orally administered for 8 days, beginning from the first morning of chemotherapy. The antiemetic effectiveness was evaluated in the first chemotherapy cycle. The incidence of acute vomiting was 33.33 % (14/42) and 54.76 % (23/42) in the intervention group and control group (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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