Characterization of an Avian Influenza A (H5N1) Virus Isolated from a Child with a Fatal Respiratory Illness
| Autor: | Keiji Fukuda, Alexander Klimov, Wilina Lim, Helen L. Regnery, Xiyan Xu, Thomas Rowe, Henrietta Hall, Michael W. Shaw, Michael L. Perdue, Nancy Cox, David E. Swayne, Kanta Subbarao, Jing Huang, Jacqueline M. Katz, Catherine A. Bender, Mark L. Hemphill |
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| Rok vydání: | 1998 |
| Předmět: |
Male
animal structures Genes Viral Molecular Sequence Data Orthomyxoviridae Influenza A (H5N1) Virus Neuraminidase Hemagglutinin Glycoproteins Influenza Virus Virus Replication medicine.disease_cause H5N1 genetic structure Virus Cell Line Disease Outbreaks Avian Influenza A Virus Fatal Outcome Influenza Human medicine Influenza A virus Animals Humans Amino Acid Sequence Phylogeny Multidisciplinary Influenza A Virus H5N1 Subtype Virulence biology virus diseases biology.organism_classification Virology Influenza A virus subtype H5N1 Child Preschool Influenza in Birds Hong Kong Female Chickens Transmission and infection of H5N1 |
| Zdroj: | Science. 279:393-396 |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.279.5349.393 |
| Popis: | An avian H5N1 influenza A virus (A/Hong Kong/156/97) was isolated from a tracheal aspirate obtained from a 3-year-old child in Hong Kong with a fatal illness consistent with influenza. Serologic analysis indicated the presence of an H5 hemagglutinin. All eight RNA segments were derived from an avian influenza A virus. The hemagglutinin contained multiple basic amino acids adjacent to the cleavage site, a feature characteristic of highly pathogenic avian influenza A viruses. The virus caused 87.5 to 100 percent mortality in experimentally inoculated White Plymouth Rock and White Leghorn chickens. These results may have implications for global influenza surveillance and planning for pandemic influenza. |
| Databáze: | OpenAIRE |
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