Changes in the clinical phenotype and behavior of pediatric luminal Crohn's disease at diagnosis in the last decade
| Autor: | Souhila Zekhnine, Lisa Djani, Valerie Marchand, Colette Deslandres, Olivier Courbette, Yi Fan Lin, Christine Cambron-Asselin, Mathieu Savoie Robichaud, Ugur Halac, Prevost Jantchou, Natalie Patey, Éric Drouin, Samuel Sassine, Kelly Grzywacz, Martha H. Dirks, Dorothée Dal Soglio, Marwa Qaddouri, Chloé Girard, Véronique Groleau |
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| Rok vydání: | 2022 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Disease Severity of Illness Index Crohn Disease Internal medicine medicine Humans Age of Onset Child Clinical phenotype Crohn's disease Granuloma Hepatology business.industry Incidence Medical record Gastroenterology medicine.disease Phenotype Disease evolution Disease Presentation Disease Progression Female Seasons business |
| Zdroj: | Digestive and Liver Disease. 54:343-351 |
| ISSN: | 1590-8658 |
| Popis: | The aims of this study were to describe the trends in the behavior of pediatric CD during the last decade and to describe the seasonal variation of disease presentation.Patients under 18 years old and diagnosed between 2009 and 2019 were included. The clinical, endoscopic, histological, and laboratory data were collected from the medical records. We analyzed the trends of these parameters according to the year and season of diagnosis.654 patients were included in the study. The number of incident CD cases increased yearly. Patients diagnosed between 2015 and 2019 were younger at diagnosis (OR 2.53, p = 0.02), had more perianal diseases (OR: 2.30, p 0.0001) and more granulomas (OR: 1.61, p = 0.003), but fewer eosinophils (OR: 0.35, p 0.0001) and less chronic lymphoplasmacytic infiltrate (OR: 0.56, p = 0.008) as compared to the 2009-2014 cohort. There was fewer CD diagnosis during winter. Patients diagnosed in the fall had lower PCDAIs, less failure to thrive and less extensive digestive involvement. Colonic disease was significantly more frequent during summer and fall.The clinical and histological phenotype of CD has changed over time and there are important seasonal trends in the frequency and severity on disease behavior suggesting possible disease triggers. |
| Databáze: | OpenAIRE |
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