Virulence-Inhibiting Herbal Compound Falcarindiol Significantly Reduced Mortality in Mice Infected with Pseudomonas aeruginosa
| Autor: | Kangmin Duan, Qiaolian Wu, Lin Chen, Pansong Zhang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Microbiology (medical)
falcarindiol Swarming motility Virulence pseudomonas aeruginosa Biology type iii secretion system medicine.disease_cause Biochemistry Microbiology antibiotics Type three secretion system 03 medical and health sciences chemistry.chemical_compound Pyocyanin medicine Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics 030304 developmental biology 0303 health sciences 030306 microbiology Pseudomonas aeruginosa lcsh:RM1-950 quorum sensing Falcarindiol Pathogenic bacteria anti-virulence therapeutic Quorum sensing lcsh:Therapeutics. Pharmacology Infectious Diseases chemistry |
| Zdroj: | Antibiotics, Vol 9, Iss 3, p 136 (2020) Antibiotics Volume 9 Issue 3 |
| ISSN: | 2079-6382 |
| DOI: | 10.3390/antibiotics9030136 |
| Popis: | Antipathogenic compounds that target the virulence of pathogenic bacteria rather than their viability offer a promising alternative approach to treat infectious diseases. Using extracts from 30 Chinese herbs that are known for treating symptoms resembling infections, we identified an active compound falcarindiol from Notopterygium incisum Ting ex H. T. Chang that showed potent inhibitory activities against Pseudomonas aeruginosa multiple virulence factors. Falcarindiol significantly repressed virulence-related genes, including the type III secretion system (T3SS) quorum sensing synthase genes lasIR and rhlIR lasB motility-related genes fliC and fliG and phenazine synthesis genes phzA1 and phzA2. P. aeruginosa swarming motility and pyocyanin production were reduced significantly. In a burned mouse model, falcarindiol treatment significantly reduced the mortality in mice infected with P. aeruginosa, indicating that falcarindiol is a promising antipathogenic drug candidate for treating P. aeruginosa infections. |
| Databáze: | OpenAIRE |
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