Cholestatic hepatitis with severe systemic reactions induced by trimethoprim-sulfamethoxazole
| Autor: | A. Nakos, N Nikolaidis, A. Koulaouzidis, Molyvas E, G Kouklakis, John Moschos, P Zezos, M Iosiphidis, A Pehlivanidis, Mpoumponaris A |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Urinary system Specialties of internal medicine urologic and male genital diseases Gastroenterology law.invention Liver disease law Internal medicine medicine drug-induced hepatitis Trimethoprim-sulfamethoxazole Hepatology medicine.diagnostic_test business.industry Sulfamethoxazole cholestatic hepatitis General Medicine bacterial infections and mycoses medicine.disease Intensive care unit Rash Trimethoprim Surgery RC581-951 Liver biopsy Prednisolone medicine.symptom business medicine.drug |
| Zdroj: | Annals of Hepatology, Vol 6, Iss 1, Pp 63-65 (2007) |
| ISSN: | 1665-2681 |
| DOI: | 10.1016/s1665-2681(19)31956-8 |
| Popis: | Trimethoprim-Sulfomethoxazole (TMP-SMX) related hepatotoxicity and associated severe systemic reaction are not frequent and documented only in case reports. We report a case of a 30-year-old man, who underwent a 15-day therapy with TMP-SMX for urinary tract infection and two weeks later developed acute cholestatic hepatitis, fever and a skin rash followed by severe systemic reaction. He was admitted in Intensive Care unit and with supportive therapy and prednisolone administration, he showed subsequent improvement over a period of few days. He had fully recovered months later. All tests for other causes of liver disease were negative and his liver biopsy showed evidence of drug-induced hepatic injury. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|