NOS1AP Is a Genetic Modifier of the Long-QT Syndrome
| Autor: | Peter J. Schwartz, Paul A. Brink, Roberto Insolia, Maria Cristina Monti, Lia Crotti, Althea Goosen, David A. Greenberg, Anna L. Peljto, Alfred L. George |
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| Přispěvatelé: | Crotti, L, Monti, M, Insolia, R, Peljto, A, Goosen, A, Brink, P, Greenberg, D, Schwartz, P, George, A |
| Rok vydání: | 2009 |
| Předmět: |
Genetic Markers
Male medicine.medical_specialty Long QT syndrome Population Sudden death QT interval Article Sudden cardiac death Death Sudden Risk Factors Physiology (medical) Internal medicine medicine Humans education Adaptor Proteins Signal Transducing Genetic association Genetics education.field_of_study long qt syndrome genetic modifier NOS1AP Genetic heterogeneity business.industry Genetic Variation Arrhythmias Cardiac MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE medicine.disease Long QT Syndrome Mutation SECS-S/01 - STATISTICA Mutation (genetic algorithm) Cardiology Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Circulation. 120:1657-1663 |
| ISSN: | 1524-4539 0009-7322 |
| DOI: | 10.1161/circulationaha.109.879643 |
| Popis: | Background— In congenital long-QT syndrome (LQTS), a genetically heterogeneous disorder that predisposes to sudden cardiac death, genetic factors other than the primary mutation may modify the probability of life-threatening events. Recent evidence indicates that common variants in NOS1AP are associated with the QT-interval duration in the general population. Methods and Results— We tested the hypothesis that common variants in NOS1AP modify the risk of clinical manifestations and the degree of QT-interval prolongation in a South African LQTS population (500 subjects, 205 mutation carriers) segregating a founder mutation in KCNQ1 (A341V) using a family-based association analysis. NOS1AP variants were significantly associated with the occurrence of symptoms (rs4657139, P =0.019; rs16847548, P =0.003), with clinical severity, as manifested by a greater probability for cardiac arrest and sudden death (rs4657139, P =0.028; rs16847548, P =0.014), and with greater likelihood of having a QT interval in the top 40% of values among all mutation carriers (rs4657139, P =0.03; rs16847548, P =0.03). Conclusions— These findings indicate that NOS1AP , a gene first identified as affecting the QTc interval in a general population, also influences sudden death risk in subjects with LQTS. The association of NOS1AP genetic variants with risk for life-threatening arrhythmias suggests that this gene is a genetic modifier of LQTS, and this knowledge may be clinically useful for risk stratification for patients with this disease, after validation in other LQTS populations. |
| Databáze: | OpenAIRE |
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