Effects of a Thermosensitive In Situ Gel Containing Mometasone Furoate on a Rat Allergic Rhinitis Model
| Autor: | Bal, Oznur, ELKIRAN, EMİN TAMER, Gunaydin, Yusuf, Menekse, Serkan, Topcu, Turkan Ozturk, Urakci, Zuhat, Tastekin, Didem, BİLİCİ, Mehmet, Cihan, Sener, UYSAL, MÜKREMİN, TANRIVERDİ, ÖZGÜR, Gumus, Mahmut, Ustaalioglu, Bala Basak Oven, Suner, Ali, Cokmert, Suna, Hacibekiroglu, Ilhan, Aydin, Kubra, Isikdogan, Abdurrahman, Inal, Ali, Kodaz, Hilmi, Geredeli, Caglayan, SEZER, EMEL, Uncu, Dogan, Arpaci, Erkan, Ozturk, Banu, Odabas, Hatice, Duran, Ayse Ocak, Seker, Mehmet Metin, Inanc, Mevlide |
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| Přispěvatelé: | AKSOY, FADLULLAH |
| Rok vydání: | 2018 |
| Předmět: |
Allergic Rhinitis
Nasal cavity Ovalbumin Mucociliary clearance medicine.medical_treatment Intraperitoneal injection Mometasone furoate Mucous membrane of nose Pharmacology Immunoglobulin E Altuntas E. Yener G. DOĞAN R. Aksoy F. Aydin M. S. Karatas E. -Effects of a Thermosensitive In Situ Gel Containing Mometasone Furoate on a Rat Allergic Rhinitis Model- AMERICAN JOURNAL OF RHINOLOGY & ALLERGY cilt.32 ss.132-138 2018 03 medical and health sciences 0302 clinical medicine Anti-Allergic Agents Suspension Immunoglobulin medicine Animals Immunology and Allergy Rats Wistar 030223 otorhinolaryngology Administration Intranasal Thermosensitive biology business.industry Intranasal Corticosteroids Temperature General Medicine Eosinophil Rhinitis Allergic Rats Disease Models Animal Histopathological Evaluation Treatment Outcome medicine.anatomical_structure Otorhinolaryngology Rat model biology.protein Female Nasal administration Mucoadhesive Nasal Cavity In Situ Gel business Gels Mometasone Furoate 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | American Journal of Rhinology & Allergy. 32:132-138 |
| ISSN: | 1945-8932 1945-8924 |
| DOI: | 10.1177/1945892418764951 |
| Popis: | WOS: 000432900700002 PubMed ID: 29644886 Background: Mometasone furoate, one of the second generation intranasal corticosteroids, is currently used in suspension form due to its poor solubility. However, this is not favorable for nasal application because of the rapid elimination of the instilled drug from the nasal cavity by mucociliary clearance and delayed onset of action due to the slow dissolution of drug in suspension. Objective: The aim of this study was to determine the antiallergic effects of mucoadhesive thermosensitive in situ gel containing mometasone furoate that we developed previously to prolong the contact between the drug and nasal mucosa and to prevent drainage of the formulation in an ovalbumin-induced rat model of allergic rhinitis. Methods: An experimental allergic rhinitis model was developed in female Wistar albino rats by intraperitoneal injection of ovalbumin every 2 days for 14 days followed by its repeated intranasal instillation for 7 consecutive days. Intranasal instillation of ovalbumin was continued every other day for 14 days. Mometasone furoate in situ gel (5 mu g/10 mu l), mometasone furoate suspension (5 mu g/10 mu l), and physiological saline (10 ml) were administered into the bilateral nasal cavities from day 22 to day 35. Antiallergic effects were evaluated through histopathological evaluation, analysis of ovalbumin-specific serum immunoglobulin E, and a symptom score. Results: Mometasone furoate in situ gel significantly decreased the nasal symptoms and ovalbumin-specific serum immunoglobulin E level as compared with mometasone furoate suspension and physiological saline. Additionally, inflammatory histological symptoms such as mucosal edema, vascular dilatation, eosinophil infiltration, and loss of cilia within the nasal mucosa of allergic rhinitis model rats were remarkably improved with the treatment of mometasone furoate in situ gel. Conclusion: These results suggest that mometasone furoate in situ gel has a better therapeutic potential for the treatment of allergic rhinitis compared to mometasone furoate suspension. Scientific Research Project Coordination Unit of Istanbul University [41584]; TUBITAK (The Scientific & Technological Research Council of Turkey) [114S820, 1002] The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by Scientific Research Project Coordination Unit of Istanbul University (Project Number: 41584) and Rapid Support Program (1002) of TUBITAK (The Scientific & Technological Research Council of Turkey (Project Number: 114S820). |
| Databáze: | OpenAIRE |
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