Designing dendrimers for ocular drug delivery
| Autor: | Vincent Soler, Carine Duhayon, Jean-Pierre Majoral, Pierre-Paul Elena, Grégory Spataro, Anne-Marie Caminade, Cédric-Olivier Turrin, François Malecaze |
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| Rok vydání: | 2009 |
| Předmět: |
Dendrimers
Carboxylic acid Static Electricity Carboxylic Acids Eye Dosage form Drug Administration Schedule chemistry.chemical_compound Dendrimer Drug Discovery medicine Organic chemistry Animals Carteolol Carboxylate Solubility Pharmacology chemistry.chemical_classification Drug Carriers Organic Chemistry Glaucoma Phosphorus General Medicine Combinatorial chemistry Quaternary Ammonium Compounds chemistry Drug Design Drug delivery Female Ocular Hypertension Rabbits Drug carrier medicine.drug |
| Zdroj: | European journal of medicinal chemistry. 45(1) |
| ISSN: | 1768-3254 |
| Popis: | New series of phosphorus-containing dendrimers, having one quaternary ammonium salt as core and carboxylic acid terminal groups have been synthesized from generation 0 (3 carboxylic acid terminal groups) to generation 2 (12 carboxylic acid terminal groups). These dendrimers react with the neutral form of carteolol (an ocular anti-hypertensive drug used to treat glaucoma) to afford ion pair (saline) species. The solubility in water of these charged dendrimers depends on the generation considered: generation 0 (3 carteolol) is well soluble, whereas generation 1 (6 carteolol) and generation 2 (12 carteolol) are poorly soluble. These dendrimers have been tested in vivo, as vehicle for ocular drug delivery of carteolol to rabbits. |
| Databáze: | OpenAIRE |
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