Why does stress aggravate itch? A possible role of the amygdala

Autor:	Darya Pavlenko, Tasuku Akiyama
Rok vydání:	2019
Předmět:	0301 basic medicine Exacerbation Dermatology Emotional processing Biochemistry Amygdala Article 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine immune system diseases parasitic diseases medicine otorhinolaryngologic diseases Animals Humans Chronic stress Chronic itch skin and connective tissue diseases Molecular Biology business.industry Pruritus Scratching Neuronal pathway eye diseases 030104 developmental biology medicine.anatomical_structure Anxiety medicine.symptom business Neuroscience Stress Psychological
Zdroj:	Exp Dermatol
ISSN:	1600-0625
Popis:	Stress is the exacerbating factor of itch across patients with chronic itch due to different origins. However, the precise mechanisms behind stress-induced exacerbation of itch remain unknown. Chronic stress induces hyperexcitability of the amygdala, the centre of emotional processing. Recent findings on the itch neuronal pathways support a pivotal role of the amygdala for itch processing. We hypothesized that itch is enhanced by stress through hyperexcitation of the amygdala. Modulation of amygdala activity, therefore, may have therapeutic potential in the treatment of chronic itch.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2edb4b5812453f7325ffab651cde249 https://pubmed.ncbi.nlm.nih.gov/30991457 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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