Placental Abnormalities Associated with Human Immunodeficiency Virus Type 1 Infection and Perinatal Transmission in Bangkok, Thailand
| Autor: | Wendy Bhanich Supapol, Timothy D. Mastro, Tuenjai Chuangsuwanich, Suthi Sungkarat, David A. Schwartz, Nathan Shaffer, Pichai Charoenpanich, Jirasak Laosakkitiboran |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Placenta Population HIV Infections Biology Chorioamnionitis Umbilical Cord Placental Membrane Cohort Studies Acquired immunodeficiency syndrome (AIDS) Pregnancy Risk Factors Funisitis Decidua medicine Humans Immunology and Allergy Prospective Studies Pregnancy Complications Infectious education education.field_of_study Obstetrics Infant Newborn Infant virus diseases Odds ratio Thailand medicine.disease Infectious Disease Transmission Vertical Infectious Diseases medicine.anatomical_structure Immunology HIV-1 Female Chorionic Villi |
| Zdroj: | The Journal of Infectious Diseases. 182:1652-1657 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1086/317634 |
| Popis: | The effects of human immunodeficiency virus (HIV) type 1 on the placenta and the role of the placenta in mother-to-child HIV-1 transmission are not well understood. Placentas from 78 HIV-infected and 158 HIV-uninfected women were examined as part of a prospective perinatal HIV transmission study in Bangkok. HIV-infected women were more likely than HIV-uninfected women to have chorioamnionitis (odds ratio [OR], 2.1; P=.03), placental membrane inflammation (PMI; OR, 2. 7; P=.02), and deciduitis (OR, 2.3; P=.03) and less likely to have villitis (OR, 0.3; P=.02). However, among HIV-infected women, fewer women who transmitted infection to their child had chorioamnionitis (relative risk [RR], 0.2; P=.03), funisitis (RR, 0.4; P=.1), or PMI (RR undefined; P=.03). These findings suggest that, in this population, HIV-infected women are at increased risk for placental membrane inflammatory lesions, but that placental inflammatory lesions are not associated with increased perinatal HIV transmission. |
| Databáze: | OpenAIRE |
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