Stellate Genes and the piRNA Pathway in Speciation and Reproductive Isolation of Drosophila melanogaster
| Autor: | Sergei S. Bazylev, Ludmila V. Olenina, Alexei A. Aravin, Vladimir E Adashev, Aleksei S Shatskikh, Alexei A. Kotov |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
endocrine system
Lineage (genetic) lcsh:QH426-470 reproductive isolation Population Piwi-interacting RNA Review Genome hybrid sterility Melanogaster Genetics education Gene Stellate genes Genetics (clinical) education.field_of_study biology piRNA pathway fungi Reproductive isolation biology.organism_classification lcsh:Genetics Molecular Medicine Drosophila Drosophila melanogaster |
| Zdroj: | Frontiers in Genetics Frontiers in Genetics, Vol 11 (2021) |
| ISSN: | 1664-8021 |
| Popis: | One of the main conditions of the species splitting from a common precursor lineage is the prevention of a gene flow between diverging populations. The study ofDrosophilainterspecific hybrids allows to reconstruct the speciation mechanisms and to identify hybrid incompatibility factors that maintain post-zygotic reproductive isolation between closely related species. The regulation, evolution, and maintenance of the testis-specificSte-Su(Ste)genetic system inDrosophila melanogasteris the subject of investigation worldwide. X-linked tandem testis-specificStellategenes encode proteins homologous to the regulatory β-subunit of protein kinase CK2, but they are permanently repressed in wild-type flies by the piRNA pathway via piRNAs originating from the homologous Y-linkedSu(Ste)locus. Derepression ofStellategenes caused bySu(Ste)piRNA biogenesis disruption leads to the accumulation of crystalline aggregates in spermatocytes, meiotic defects and male sterility. In this review we summarize current data about the origin, organization, evolution of theSte-Su(Ste)system, and piRNA-dependent regulation ofStellateexpression. TheSte-Su(Ste)system is fixed only in theD. melanogastergenome. According to our hypothesis, the acquisition of theSte-Su(Ste)system by a part of the ancient fly population appears to be the causative factor of hybrid sterility in crosses of female flies with males that do not carry Y-linkedSu(Ste)repeats. To support this scenario, we have directly demonstratedStellatederepression and the corresponding meiotic disorders in the testes of interspecies hybrids betweenD. melanogasterandD. mauritiana. This finding embraces our hypothesis about the contribution of theSte-Su(Ste)system and the piRNA pathway to the emergence of reproductive isolation ofD. melanogasterlineage from initial species. |
| Databáze: | OpenAIRE |
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