Blueberry extract as a potential pharmacological tool for preventing depressive-like behavior and neurochemical dysfunctions in mice exposed to lipopolysaccharide
Autor: | Karina Pereira Luduvico, Anelize de Oliveira Campello Felix, Pathise Souto Oliveira, Natália Pontes Bona, Luiza Spohr, Julia Eisenhardt de Mello, Francieli Moro Stefanello, Mayara Sandrielly Pereira Soares, Fernando Lopez Alvez, Roselia Maria Spanevello, Fernanda Cardoso Teixeira |
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Rok vydání: | 2020 |
Předmět: |
Lipopolysaccharides
0301 basic medicine Antioxidant medicine.medical_treatment Blueberry Plants Medicine (miscellaneous) macromolecular substances Pharmacology medicine.disease_cause Hippocampus Thiobarbituric Acid Reactive Substances Neuroprotection Mice 03 medical and health sciences 0302 clinical medicine Neurochemical medicine Animals Humans Depression (differential diagnoses) Neuroinflammation Depressive Disorder Major 030109 nutrition & dietetics Nutrition and Dietetics Behavior Animal biology Depression Plant Extracts Vaccinium virgatum business.industry General Neuroscience General Medicine biology.organism_classification medicine.disease Oxidative Stress Major depressive disorder business 030217 neurology & neurosurgery Oxidative stress |
Zdroj: | Nutritional Neuroscience. 25:857-870 |
ISSN: | 1476-8305 1028-415X |
Popis: | Major depressive disorder is a debilitating and recurrent psychiatric disorder. Blueberries have several biological properties, including neuroprotective effects, through antioxidant and anti-inflammatory actions. The aim of this study was to evaluate the effect of blueberry extract on depressive-like behavior and lipopolysaccharide (LPS)-induced neurochemical changes.Mice were pretreated with vehicle, fluoxetine (20 mg/kg) or blueberry extract (100 or 200 mg/kg) intragastrically for seven days before intraperitoneal LPS (0.83 mg/kg) injection. Twenty-four hours after LPS administration, mice were submitted to behavioral tests. Oxidative stress and neuroinflammatory parameters were evaluated in the cerebral cortex, hippocampus, and striatum.Our data showed that blueberry extract or fluoxetine treatment protected against LPS-induced depressive-like behavior in tail suspension and splash tests (This study showed that blueberry extract exerted antidepressant-like effects, protected the brain against oxidative damage, and modulated TNF-α levels induced by LPS. |
Databáze: | OpenAIRE |
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