Thrombin Generation in Chronic Liver Diseases—A Pilot Study
| Autor: | Liliana Vecerzan, Ariela Olteanu, Horaţiu Dura, Sorin Radu Fleaca, Călin Remus Cipăian, Adrian Boicean, Romeo-Gabriel Mihaila, Ionela Maniu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Cirrhosis Leadership and Management liver cirrhosis Health Informatics Disease 030204 cardiovascular system & hematology Chronic liver disease Gastroenterology Article 03 medical and health sciences 0302 clinical medicine Thrombin Health Information Management Internal medicine medicine coagulation Coagulation Disorder Hepatitis business.industry Health Policy medicine.disease Coagulation thrombin generation Etiology Medicine 030211 gastroenterology & hepatology chronic hepatitis business medicine.drug |
| Zdroj: | Healthcare Volume 9 Issue 5 Healthcare, Vol 9, Iss 550, p 550 (2021) |
| ISSN: | 2227-9032 |
| DOI: | 10.3390/healthcare9050550 |
| Popis: | The knowledge about coagulation disorders in patients with chronic liver disease changed in the last decade. The aim of this study was to analyze the parameters of thrombin generation in patients with chronic liver disease, as they are the most appropriate biomarkers to explore coagulation. (1) Background: The knowledge about coagulation disorders in patients with chronic liver disease changed in the last decade. The study of thrombin generation in patients with chronic liver disease provides a much more accurate assessment of the coagulation cascade (2) Methods: This study is a prospective observational pilot study on hospitalized patients with chronic liver diseases that analyzed thrombin generation performed from their platelet-poor plasma versus that of control subjects. We analyzed a group of 59 patients with chronic liver disease and 62 control subjects (3) Results: Thrombin generation was lower in hepatitis and cirrhosis patients compared to controls and decreases as the disease progressed. Lag time was higher in ethanolic etiology compared to the control group. Peak thrombin and endogenous thrombin potential were shorter in all etiologies when compared to the control group. The velocity index was significantly lower in HCV hepatopathies, ethanolic, and mixed etiology when compared with normal individuals (4) Conclusions: Given the variability of thrombin generation in patients with chronic liver disease, its assay could serve to identify patients with high thrombotic and hemorrhagic risk and establish personalized conduct toward them. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|