Effects of abamectin exposure on male fertility in rats: Potential role of oxidative stress-mediated poly(ADP-ribose) polymerase (PARP) activation
| Autor: | Ramazan Demir, Mehmet Isbir, Ciler Celik-Ozenci, Leyla Sati, Ece Gungor, Arda Tasatargil, Merih Tekcan |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Insecticides medicine.medical_specialty Poly ADP ribose polymerase Oxidative phosphorylation Biology Toxicology medicine.disease_cause Male infertility Rats Sprague-Dawley chemistry.chemical_compound Internal medicine Testis medicine Animals Spermatogenesis Epididymis Ivermectin Sperm Count General Medicine medicine.disease Sperm Rats Oxidative Stress Fertility Seminiferous tubule medicine.anatomical_structure Endocrinology chemistry Sperm Motility Abamectin Follicle Stimulating Hormone Poly(ADP-ribose) Polymerases Oxidative stress Hormone |
| Zdroj: | Regulatory Toxicology and Pharmacology. 61:310-317 |
| ISSN: | 0273-2300 |
| DOI: | 10.1016/j.yrtph.2011.09.001 |
| Popis: | Despite the known adverse effects of abamectin pesticide, little is known about its action on male fertility. To explore the effects of exposure to abamectin on male fertility and its mechanism, low (1 mg/kg/day) and high dose (4 mg/kg/day) abamectin were applied to male rats by oral gavage for 1 week and for 6 weeks. Weight of testes, serum reproductive hormone levels, sperm dynamics and histopathology of testes were used to evaluate the reproductive efficiency of abamectin-exposed rats. Abamectin level was determined at high concentrations in plasma and testicular tissues of male rats exposed to this pesticide. The testes weights of animals and serum testosterone concentrations did not show any significant changes after abamectin exposure. Abamectin administration was associated with decreased sperm count and motility and increased seminiferous tubule damage. In addition, significant elevations in the 4-hydroxy-2-nonenal (4-HNE)-modified proteins and poly(ADP-ribose) (PAR) expression, as markers for oxidative stress and poly(ADP-ribose) polymerase (PARP) activation, were observed in testes of rats exposed to abamectin. These results showed that abamectin exposure induces testicular damage and affects sperm dynamics. Oxidative stress-mediated PARP activation might be one of the possible mechanism(s) underlying testicular damage induced by abamectin. (C) 2011 Elsevier Inc. All rights reserved. |
| Databáze: | OpenAIRE |
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