Thiol-disulphide balance in infertility secondary to varicocele
| Autor: | Soner Coban, Ugur Akgun, Ahmet Rifat Balik, Ozcan Erel, İbrahim Keleş, Yasemin Ustundag, Muhammet Guzelsoy, Mustafa Murat Aydos, Ali Riza Turkoglu |
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| Rok vydání: | 2019 |
| Předmět: |
Infertility
Adult Male medicine.medical_specialty Adolescent Urology Varicocele 030232 urology & nephrology Serum Albumin Human Veins 03 medical and health sciences Young Adult 0302 clinical medicine Endocrinology Risk Factors Internal medicine medicine Homeostasis Humans Disulfides Prospective Studies Sulfhydryl Compounds Vein Spermatic Vein Infertility Male chemistry.chemical_classification Spermatic Cord Median cubital vein 030219 obstetrics & reproductive medicine Albumin General Medicine Venous blood Middle Aged medicine.disease Oxidative Stress medicine.anatomical_structure chemistry Thiol Biomarkers |
| Zdroj: | Andrologia. 51(8) |
| ISSN: | 1439-0272 |
| Popis: | Oxidative stress plays an important role in the development of infertility secondary to varicocele. We aimed to investigate the dynamic thiol-disulphide homeostasis as an oxidative stress marker in the spermatic vein of infertility secondary to varicocele. Sixty-one patients with varicocele were included in the study. Blood was drawn from the median cubital vein and the testicular venous return side before the spermatic vein was separated during surgery. Total thiol, native thiol, disulphide, ischaemia modified albumin (IMA) and albumin values were measured from both the dilated spermatic vein and the median cubital vein. The disulphide/native thiol, disulphide/total thiol and native thiol/total thiol ratios were determined. The mean age of the patients was 27.0 ± 6.68 (15-50) years. While the albumin, native thiol and total thiol values and the native thiol/total thiol ratio were significantly lower (p = 0.004, p |
| Databáze: | OpenAIRE |
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