Clinical Relevance of Therapeutic Drug Monitoring of Digoxin and Gentamicin in the Saliva of Children
| Autor: | Gideon Koren, Zehava Chen-Levi, Pascale Burtin, Mordechai Aladjem, Tamir Dagan, Matitiahu Berkovitch, Robert M. Freedom, Tzvy Bistritzer |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
Digoxin Saliva Cardiotonic Agents Pharmacology Pharmacokinetics Saliva testing medicine Humans Pharmacology (medical) Antibacterial agent medicine.diagnostic_test business.industry Aminoglycoside Infant Newborn Infant Anti-Bacterial Agents Therapeutic drug monitoring Child Preschool Female Drug Monitoring Gentamicins business medicine.drug Blood sampling |
| Zdroj: | Therapeutic Drug Monitoring. 20:253-256 |
| ISSN: | 0163-4356 |
| DOI: | 10.1097/00007691-199806000-00003 |
| Popis: | Digoxin and gentamicin are widely used in pediatric medicine, and therapeutic monitoring is mandatory because of their narrow margin of safety and wide interpatient and intrapatient pharmacokinetic variabilities. Saliva sampling may be of potential interest, especially in children, in whom blood sampling is often difficult. In 11 children treated with digoxin for various cardiac conditions, and in 24 children treated with gentamicin (14 patients were administered gentamicin three times a day, and 10 once-daily), drugs levels were measured in plasma and saliva. There was no correlation between plasma total or free digoxin concentrations and saliva levels, precluding the clinical use of the saliva test for digoxin. No correlation was found between plasma gentamicin concentrations and saliva levels when the drug was administered three times a day; however, good correlation was found when the drug was administered once-daily (r2 = 0.89, p < 0.0001). Saliva may be used as a noninvasive method of measuring gentamicin serum concentrations to guide dosage adjustments in patients administered the drug once-daily. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|