Alterations of alpha1-adrenoceptor subtypes in the hearts of thyroxine-treated rats
| Autor: | Youyi Zhang, Peng Qu, Erdan Dong, Kaimin Xu, Gengsheng Yu, Chide Han |
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| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty Thyroid Hormones Molecular Sequence Data Adrenergic Biology Polymerase Chain Reaction Internal medicine Receptors Adrenergic alpha-1 Gene expression Phenethylamines medicine Animals RNA Messenger Rats Wistar Receptor Phenylephrine Tetralones Pharmacology Messenger RNA Base Sequence Contractile response Heart α1 adrenoceptor Myocardial Contraction Rats Thyroxine Endocrinology Chlorethylclonidine medicine.drug |
| Zdroj: | European journal of pharmacology. 294(2-3) |
| ISSN: | 0014-2999 |
| Popis: | Alterations in the cardiac alpha1-adrenoceptor and its subtypes in thyroxine-treated rats were studied by means of radioligand binding assays, measurement of contractile response and reverse transcription-polymerase chain reaction (RT-PCR). The results showed that in thyroxine-treated rats the cardiac alpha1-adrenoceptor density (Bmax) was reduced from 51.6 +/- 6.0 fmol/mg in control to 40.9 +/- 3.7 fmol/mg (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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