Study of Body Composition, Lung Function, and Quality of Life Following Use of Anabolic Steroids in Patients With Chronic Obstructive Pulmonary Disease
| Autor: | Mradul Kumar Daga, Govind Mawari, Suman Kumar, Varun Kumar Malhotra, Naushad Ahmad Khan, Harmanjit Singh Hira |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Anabolism medicine.medical_treatment Medicine (miscellaneous) Walking Pulmonary function testing law.invention Pulmonary Disease Chronic Obstructive Anabolic Agents Double-Blind Method Quality of life Randomized controlled trial Weight loss law Internal medicine Activities of Daily Living medicine Humans Nandrolone Lung Aged COPD Nutrition and Dietetics Anthropometry business.industry Middle Aged medicine.disease Nandrolone Decanoate Physical Fitness Dietary Supplements Body Composition Exercise Test Quality of Life Physical therapy Cardiology Arterial blood medicine.symptom business Anabolic steroid |
| Zdroj: | Nutrition in Clinical Practice. 29:238-245 |
| ISSN: | 1941-2452 0884-5336 |
| Popis: | Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow limitation and is associated with weight loss and decreased muscle strength and exercise capacity.A double-blinded randomized controlled trial of 32 male COPD patients (age, 54.94 ± 11.27 years) was carried out to assess effects of anabolic steroid in terms of a daily high-protein, high-calorie diet alone or one combined with anabolic steroids on body composition, lung function, and health-related quality of life (HRQL). Outcomes were assessed by anthropometric and spirometric measurements, peak expiratory flow rate, partial pressure of oxygen in arterial blood, 6-minute walk test (6MWT), hand grip test, and HRQL index scores. Measurements were made at baseline and end of treatment (6 weeks).All patients showed significant difference (P.001) in pulmonary function parameters and anthropometric measurements after 6 weeks of intervention (within-group changes); however, no significant improvement occurred in the pulmonary function parameters between the groups. The difference in exercise capacity (6MWT) and HRQL scores in the treatment group were statistically significant (P.001) compared with control group after 6 weeks of intervention. In the treatment group, the average 6MWT distance increased from 213.5 m to 268.5 m at 6-week follow-up, and HRQL scores increased from 101.25 to 118.45. Also, HRQL and 6MWT parameters were positively correlated in response to steroid supplementation at the end of the study.Weekly administration of anabolic steroids during 6 weeks increased exercise capacity and quality of life in patients with COPD. |
| Databáze: | OpenAIRE |
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