Scanning photoacoustic imaging of submucosal gastric tumor based on a long focused transducer in phantom and in vitro experiments
| Autor: | Huaqin Wu, Hui Li, Shulian Wu, Wenming Xie, Xiaoman Zhang, Zhifang Li, Hao-Yu Wang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Materials science
media_common.quotation_subject gastric tumor detection Biomedical Engineering Medicine (miscellaneous) Photoacoustic imaging in biomedicine lcsh:Technology 01 natural sciences Imaging phantom Ionizing radiation 010309 optics 03 medical and health sciences 0103 physical sciences lcsh:QC350-467 Contrast (vision) Gastric tumor 030304 developmental biology media_common Maximum intensity 0303 health sciences lcsh:T Column diffusion fiber Atomic and Molecular Physics and Optics Electronic Optical and Magnetic Materials long focusing transducer Depth imaging Transducer scanning photoacoustic tomography phantom experiment lcsh:Optics. Light Biomedical engineering |
| Zdroj: | Journal of Innovative Optical Health Sciences, Vol 12, Iss 3, Pp 1950011-1-1950011-12 (2019) |
| ISSN: | 1793-7205 1793-5458 |
| DOI: | 10.1142/s1793545819500111 |
| Popis: | Photoacoustic imaging, which can provide the maximum intensity contrast in tissue depth imaging without ionizing radiation, will be a promising imaging trend for tumor detection. In this paper, a column diffusion fiber was employed to carry a pulsed laser for irradiating stomach directly through esophagus based on the characteristics of gastric tissue structure. A long focused ultrasonic transducer was placed outside the body to detect photoacoustic signals of gastric tissue. Phantom and in vitro experiments of submucosal gastric tumors were carried out to check the sensitivity of scanning photoacoustic tomography system, including the lateral and longitudinal resolution of the system, sensitivity of different absorption coefficient in imaging, capability of transversal detection, and probability of longitudinal detection. The results demonstrate that our innovative technique can improve the parameters of imaging. The lateral resolution reaches 2.09[Formula: see text]mm. Then a depth of 5.5[Formula: see text]mm with a longitudinal accuracy of 0.36[Formula: see text]mm below gastric mucosa of early gastric cancer (EGC) has been achieved. In addition, the optimal absorption coefficient differences among absorbers of system are 3.3–3.9 times. Results indicate that our photoacoustic imaging (PAI) system, is based on a long focusing transducer, can provide a potential application for detecting submucosal EGC without obvious symptoms. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|