Prime-boost AIDS Vaccine Strategies Based on Replication-Competent Adenovirus Recombinants
| Autor: | Marjorie Robert-Guroff, David Venzon, Susan W. Barnett, L. Jean Patterson, V. Raúl Gómez-Román, Nina Malkevitch, Bo Peng, Indresh K. Srivastava, Ruth H. Florese |
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| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Antibody-dependent cell-mediated cytotoxicity
lcsh:Immunologic diseases. Allergy Cellular immunity biology animal diseases Priming (immunology) Prime boost medicine.disease Virology Infectious Diseases Acquired immunodeficiency syndrome (AIDS) Immunity Immunology biology.protein medicine Antibody lcsh:RC581-607 Mucosal immunity |
| Zdroj: | Retrovirology, Vol 2, Iss Suppl 1, p S64 (2005) |
| ISSN: | 1742-4690 |
| Popis: | The potent, persistent immunity needed to prevent HIV infection might be best achieved by priming cellular immunity with replicating vectors and boosting antibodies with optimally designed envelopes. Replicating Ad vaccines infect epithelial cells on mucosal surfaces and thus also elicit mucosal immunity. In chimpanzees, compared to non-replicating Ad vaccines, at the same or lower dose replicating Ad vaccines were better at eliciting cellular immunity and priming antibody responses. Mismatched envelope boosts induced broad neutralizing activity to diverse R5 viruses and cross-clade ADCC activity. Multigenic Ad-SIV vaccines and SIV envelope subunit boosts elicited strong protection in 39% of rhesus macaques challenged mucosally with SIVmac251. Durability of protection against a second challenge was established in 73% of previously protected animals, associated with persistent cellular immunity. Induction of memory cells and broad, strong functional antibodies illustrates the promise of this prime-boost vaccine strategy. from 2005 International Meeting of The Institute of Human Virology Baltimore, USA, 29 August – 2 September 2005 |
| Databáze: | OpenAIRE |
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