Serum adiponectin levels are associated with presence of carotid plaque in women with systemic lupus erythematosus

Autor: Barbara Maria Colombo, Flavio Nobili, Federico Carbone, Alessandro Poggi, Fabrizio Montecucco, Fabio Cacciapaglia, Antonella Afeltra, Tiziano Moccetti
Přispěvatelé: University of Zurich, Carbone, Federico
Rok vydání: 2020
Předmět:
Carotid Artery Diseases
Time Factors
Endocrinology
Diabetes and Metabolism
Medicine (miscellaneous)
Disease
030204 cardiovascular system & hematology
Gastroenterology
0302 clinical medicine
Adrenal Cortex Hormones
Risk Factors
Prevalence
Lupus Erythematosus
Systemic
Medicine
Adipocytokines
Serum adiponectin
Leptin resistin
Nutrition and Dietetics
Leptin
2701 Medicine (miscellaneous)
Adiponectin
Atherosclerosis
Systemic lupus erythematosus
Middle Aged
Prognosis
Plaque
Atherosclerotic
Up-Regulation
2712 Endocrinology
Diabetes and Metabolism
Italy
Cohort
Disease Progression
2916 Nutrition and Dietetics
Female
Cardiology and Cardiovascular Medicine
Immunosuppressive Agents
Adult
medicine.medical_specialty
Adolescent
Adipokine
610 Medicine & health
030209 endocrinology & metabolism
11171 Cardiocentro Ticino
2705 Cardiology and Cardiovascular Medicine
Young Adult
03 medical and health sciences
Sex Factors
Internal medicine
Humans
Aged
business.industry
Resistin
business
Biomarkers
Blood sampling
Zdroj: Nutrition, Metabolism and Cardiovascular Diseases. 30:1147-1151
ISSN: 0939-4753
DOI: 10.1016/j.numecd.2020.03.020
Popis: Background and aim Systemic lupus erythematosus (SLE) is associated with accelerated atherogenesis. Traditional risk factors do not seem to fully explain this process in patients with SLE and no other imaging/serum biomarkers have so far improved risk stratification. Here, we focused on the role of adiponectin in women with SLE. Methods and results This is a sub-analysis of a validated cohort enrolling eighty females (age 18–65 years) affected by SLE. Patient underwent a single blood sampling and carotid echography. Serum adipocytokines (i.e. leptin, resistin and adiponectin) were assessed by enzyme-linked immunosorbent assay (ELISA). Patients with a carotid plaque (n = 23) were older, with longer duration of the disease, chronic use of corticosteroids, and immunosuppressive therapies. As expected, patients with a carotid plaque had increased vascular risk and high serum levels of inflammatory biomarkers, total and LDL cholesterol and adiponectin. Significant positive correlation between serum adiponectin and presence of a carotid plaque was found independently of patient age, SCORE Risk Charts, duration of disease, and SLE treatments. Conclusions These results indicate that high serum adiponectin is associated with accelerated carotid atherosclerosis in SLE young women and it might be useful to improve vascular risk stratification in this patient setting.
Databáze: OpenAIRE
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