Molecular epidemiology of Legionnaires' disease in Israel
| Autor: | Jacob Moran-Gilad, M. Mentasti, T. Shahar, Emilia Anis, T Lazarovitch, T. Stocki, C. Sadik, Timothy G. Harrison, Z. Huberman, Lea Valinsky, Itamar Grotto |
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| Rok vydání: | 2013 |
| Předmět: |
Microbiology (medical)
Serotype Adult Male medicine.medical_specialty Adolescent Genotype Legionella Serogroup Legionella pneumophila Microbiology Young Adult Internal medicine Epidemiology Prevalence Medicine Humans Typing Israel Serotyping Child Aged Aged 80 and over Molecular Epidemiology biology Molecular epidemiology business.industry Incidence (epidemiology) typing Infant General Medicine Middle Aged biology.organism_classification medicine.disease Molecular Typing Infectious Diseases Legionnaires‘ disease Child Preschool Legionnaires' disease Female Legionnaires' Disease business |
| Zdroj: | Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 20(7) |
| ISSN: | 1469-0691 |
| Popis: | National surveillance of Legionnaires‘ disease (LD) is important to inform control measures and facilitate international networking for timely reporting. This study is the first to describe the molecular epidemiology of LD in Israel. Case notifications for 2006–2011, collated through mandatory reporting, were identified and demographic, clinical and laboratory data were extracted. Unrelated clinical and environmental Legionella pneumophila strains were characterized using standard procedures, Dresden panel of monoclonal antibodies and the ESCMID Study Group for Legionella Infections (ESGLI) Sequence-Based Typing scheme. In all, 294 cases were reported (crude incidence 0.67 cases/100 000; age-standardized incidence 1/100 000). LD epidemiological trends and features largely resembled those of the EU, except for a larger proportion of nosocomial cases. Of 28 clinical and 23 environmental strains analysed, 71.4% and 21.7% were serogroup (sg) 1 and the most common immunological subgroup was OLDA/Oxford (64%). Of the clinical strains, OLDA/Oxford, ST1 was the most common (43%) followed by Allentown/France, ST40 (14%). The unusual sg 3 ST338 was found in 17.4% of environmental strains. Novel STs were detected amongst 23.5% of strains. These findings warrant further molecular investigation. Molecular epidemiology data generated from neighbouring countries newly adopting the ESGLI typing scheme for L. pneumophila contribute to understanding of regional strain diversity. |
| Databáze: | OpenAIRE |
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