Renal function in relation to three candidate genes
| Autor: | Laura Tizzoni, Willem H. Birkenhäger, Stefan-Martin Herrmann, Eva Brand, Jan A. Staessen, Ji-Guang Wang, Giuseppe Bianchi, Robert Fagard |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Aldosterone synthase medicine.medical_specialty Adolescent Genotype Population Renal function Peptidyl-Dipeptidase A Kidney Function Tests White People chemistry.chemical_compound Gene Frequency Internal medicine medicine Humans Child education Aged TRPC Cation Channels Aged 80 and over Creatinine education.field_of_study Kidney Polymorphism Genetic Proteinuria biology business.industry Middle Aged medicine.disease Cross-Sectional Studies Endocrinology Blood pressure medicine.anatomical_structure chemistry Nephrology Hypertension biology.protein Calmodulin-Binding Proteins Female Calcium Channels medicine.symptom business Kidney disease |
| Zdroj: | American Journal of Kidney Diseases. 38:1158-1168 |
| ISSN: | 0272-6386 |
| DOI: | 10.1053/ajkd.2001.29205 |
| Popis: | We recently found that femoral intima media thickness, as well as the incidence of hypertension, is influenced by genes encoding the angiotensin-converting enzyme (ACE; insertion/deletion [I/D]) polymorphism, alpha-adducin (Gly460Trp), and aldosterone synthase (-344C/T). By interfering with blood pressure or sodium homeostasis, these genetic polymorphisms also may change renal function. We therefore investigated serum creatinine level, calculated and measured creatinine clearances, and 24-hour urinary protein excretion in subjects previously genotyped for these three polymorphisms. The 1,454 participants drawn at random from the population (64.3% of those invited) were aged 43.4 years and included 744 women (51.2%). Blood pressure, measured by study nurses at subjects' homes, averaged 123/76 mm Hg. Mean values were 90 micromol/L for serum creatinine; 84 and 88 mL/min/1.73 m(2) for calculated and measured (n = 855) creatinine clearances, respectively; and 90 mg/d of protein for proteinuria (n = 556). The prevalence of mild renal dysfunction (creatinine clearance |
| Databáze: | OpenAIRE |
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