Determination of primary aromatic amines in cold water extract of coloured paper napkin samples by liquid chromatography-tandem mass spectrometry
| Autor: | Eddo Hoekstra, Sandro Valzacchi, Catherine Simoneau, Oguzhan Yavuz |
|---|---|
| Přispěvatelé: | OMÜ |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Paper
Toluidines Health Toxicology and Mutagenesis Coloring agents Food Contamination 010501 environmental sciences Toxicology 01 natural sciences Uhplc ms ms Article Liquid chromatography–mass spectrometry Tandem Mass Spectrometry paper napkins media_common.cataloged_instance Humans Primary aromatic amines (PAAs) European union Amines Coloring Agents 0105 earth and related environmental sciences media_common Chromatography Aniline Compounds Food contact Chemistry 010401 analytical chemistry Public Health Environmental and Occupational Health Chromatography liquid Water General Chemistry General Medicine Original Articles Cooking and Eating Utensils cold water extract 0104 chemical sciences Europe Environmental chemistry UHPLC-MS/MS Carcinogens Maximum Allowable Concentration Food Science Food contaminant International agency Chromatography Liquid |
| Zdroj: | Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment |
| DOI: | 10.1080/19440049.2016.1184493 |
| Popis: | WOS: 000380137500017 PubMed: 27146949 The aim of this study was the optimisation of a multi-analyte method for the analysis of primary aromatic amines ( PAAs) from napkins in order to support official controls and food safety. We developed a UHPLC- MS/ MS method for the simultaneous determination of 36 toxicologically relevant PAAs for paper and board. Good regression coefficients of the calibration curves in a range of 0.992- 0.999 and reproducibilities in a range of 2.3- 15% were obtained. Limits of detections ( LODs) were in the range of 0.03-1.4 mu g l(-1) and recoveries were in a range of 21-110% for all the amines. A total of 93 coloured paper napkin samples from different European countries were bought and extracted with water to determine the PAAs. The results showed that 42 of 93 samples contained at least one PAA. More than half of the detected PAAs are considered as toxic, carcinogenic or probably carcinogenic to humans by the International Agency for Research on Cancer ( IARC), or are classified as such in the European Union legislation on chemicals. Summed concentrations of PAAs in seven samples were higher than 10 mu g l(-1), the limit of summed PAA in the European Union plastic food contact material regulation. Also, eight PAAs, classified as Category 1A and 1B carcinogen in the European Union legislation of chemicals, were detected at concentrations higher than 2 mu g l(-1), exceeding the limit proposed by the Federal Institute for Risk Assessment in Germany. Aniline ( n = 14) was most frequently present in higher concentrations followed by o-toluidine, o-anisidine, 2,4-dimethylaniline and 4-aminoazobenzene. Red, orange, yellow and multicoloured paper napkins contained the highest concentrations of total PAAs (> 10 mu g l(-1)). Although the European Union has not harmonised the legislation of paper and board materials and, thus, there is no specific migration limit for PAAs from paper napkins, the present study showed that coloured paper napkins can contain toxic and carcinogenic PAAs at concentrations that are relevant for monitoring. |
| Databáze: | OpenAIRE |
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