Seasonal variations in properties of healthy and diabetic rat heart mitochondria: Mg2+-ATPase activity, content of conjugated dienes and membrane fluidity
| Autor: | Jana Mujkosova, M Ferko, P Humeník, Attila Ziegelhöffer, Iveta Waczulíková |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Membrane Fluidity Physiology Diabetic rat ATPase Conjugated system Mitochondrion Diabetic heart Mitochondria Heart Diabetes Mellitus Experimental Membrane Lipids Internal medicine medicine Membrane fluidity Animals Rats Wistar Lipid bilayer biology General Medicine Rats Endocrinology Membrane Mitochondrial Membranes biology.protein Ca(2+) Mg(2+)-ATPase Lipid Peroxidation Seasons |
| Zdroj: | Physiological Research. :S75-S82 |
| ISSN: | 1802-9973 0862-8408 |
| DOI: | 10.33549/physiolres.931555 |
| Popis: | Our previous preliminary results pointed to possible seasonal variations in Mg2+-ATPase activity of rat heart mitochondria (MIT). It is not too surprising since seasonal differences were already reported in myocardial function, metabolism and ultrastructure of the intact as well as hemodynamically overloaded rabbit hearts and also in other tissues. The present study is aimed to elucidate whether seasonal differences observed in rat heart MIT Mg2+-ATPase activity will be accompanied with changes in membrane fluidity and in the content of conjugated dienes (CD) in the lipid bilayers of MIT membranes as well as whether the above seasonal differences will also be present in the diabetic heart. Our results revealed that values of Mg2+-ATPase activity in the winter/spring-period (W/S-P) exceeded significantly (p |
| Databáze: | OpenAIRE |
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