Investigation of type 3 poliovirus variants with increased L-cystine-dependence as live vaccines
| Autor: | A. V. Tyufanov, G. A. Alpatova, G. L. Krutyanskaya, I. S. Sokolova, El'bert Lb, Chumakov Mp, N. M. Ralph |
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| Rok vydání: | 1971 |
| Předmět: |
Adult
Central Nervous System Genetics Microbial medicine.medical_specialty Time Factors Virus Cultivation Adolescent Statistics as Topic Cystine Biology Kidney Virus Replication medicine.disease_cause Microbiology Feces chemistry.chemical_compound Tissue culture Medical microbiology Culture Techniques Virology medicine Animals Humans Child Virulence Poliovirus Vaccination Genetic Variation Stereoisomerism Haplorhini General Medicine medicine.disease Phenotype Poliomyelitis chemistry Evaluation Studies as Topic Genetic marker Poliovirus Vaccine Oral Antibody Formation Macaca |
| Zdroj: | Archiv f�r die gesamte Virusforschung. 33:259-270 |
| ISSN: | 1432-8798 0304-8608 |
| Popis: | Highly attenuated cystine-dependent variants of two type 3 poliovirus strains (one vaccine and one “wild”) were capable of implantation in the alimentary tract of children, prolonged circulation in the groups of children and induction of specific antibody response. Deviations of intestinal isolates from the phenotype of the original vaccines by the cystine, d and rct/40 markers and neurovirulence for monkeys were demonstrated. An assumption is made concerning the cause of the lack of significant positive effect of an additional Cyd mutation on the genetic stability of the vaccines in the human organism. |
| Databáze: | OpenAIRE |
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